1. Schizophrenia’s Heterogeneity

2. Schizophrenia’s Heterogeneity
Positive
Neuro/Motor
Affective
Negative
Social Cognition
Disorganization
Neurocognition
Anxiety
OCS

3. Major Tranquilizers, Neuroleptics, Antipsychotics…
1930s s s s
FIRST GENERATION SECOND GENERATION THIRD…
Clozapine
Zotepine
Amisulpride
Reserpine
Asenapine
Lurasidone
Olanzapine
Paliperidone
Quetiapine
Risperidone
Remoxipride*
Sertindole*
Ziprasidone
Chlorpromazine
Aripiprazole
Haloperidol
Fluphenazine
Pimozide
*withdrawn
Adapted: Muller-Spahn 2002