1. Upper panel shows a biopsy sample obtained from a normal volunteer and stained with periodic acid–Schiff (PAS) stain. The glycoprotein-rich epithelial cell brush border and the goblet cell mucous are PAS-positive. The biopsy sample in the lower panel was obtained from a patient with untreated Whipple disease. The villus architecture is markedly distorted and the lamina propria is packed with large PAS-positive macrophages that virtually replace the lymphocytes and plasma cells that would normally be seen. Additionally, profiles of dilated lymphatics are evident in the lamina propria.
Source: Color Plates, CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e
Citation: Greenberger NJ, Blumberg RS, Burakoff R. CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 3e; 2016 Available at: Accessed: October 21, 2017
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