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SURVEY OF BIOCHEMISTRY Nucleic Acids

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Presentation on theme: "SURVEY OF BIOCHEMISTRY Nucleic Acids"— Presentation transcript:

1 SURVEY OF BIOCHEMISTRY Nucleic Acids

2 What are nucleic acids? Building blocks of genetic material that a cell uses to direct cellular functions and heredity 3 Components: Sugar Moiety Ribose (in RNA) Deoxyribose (in DNA)

3 Ring Numbering in Ribose
5’ 4’ 1’ DNA lacks the 2’-OH group 3’ 2’

4 What are nucleic acids? Building blocks of genetic material that a cell uses to direct cellular functions and heredity 3 Components: Phosphate Moiety Phosphate Group Phosphoric Acid

5 What are nucleic acids? Building blocks of genetic material that a cell uses to direct cellular functions and heredity 3 Components: 5 Nitrogenous Bases Guanine G PURINES Adenine A

6 What are nucleic acids? Building blocks of genetic material that a cell uses to direct cellular functions and heredity 3 Components: 5 Nitrogenous Bases Cytosine C Thymine T Uracil U PYRIMIDINES

7 Ring Numbering in Bases
Adenine A 6 7 5 1 8 2 4 9 3

8 Ring Numbering in Bases
Cytosine C 4 5 3 2 6 1

9 Nomenclature Base Nucleoside Nucleotide
Adenine Adenosine Adenosine A Monophosphate Guanine Guanosine Guanosine G Monophosphate Etc. Study Table 3-1 for more details…

10 How do nucleotides link?

11 Base Pairing Carbon Nitrogen Oxygen Hydrogen

12 Base Pairing Carbon Nitrogen Oxygen Hydrogen

13 How Does RNA Differ from DNA?
Ribose vs. Deoxyribose Bases and Base Pairing T in DNA vs. U in RNA A-T in DNA vs. A-U in RNA 3D Structure Role

14 Protein Data Bank

15 Protein Data Bank Download PDB file to Desktop
Use Freeware to View Contents RasMol PyMol Swiss PDB Viewer Protein Explorer

16 Software for Viewing Structures
Rasmol Pymol SwissPDB Viewer Protein Explorer

17 DNA Double Helix

18 DNA Structural Features
Handedness Anti-parallel strands Major and minor grooves

19 Different Conformations of DNA

20 DNA has incredible flexibility!
Catabolite- Activator Protein (CAP) + DNA Yale (1991)

21 DNA has incredible flexibility!
DNA Octahedron Ned Seeman NYU International Society for Nanoscale Science, Computation, and Engineering

22 Limitations to DNA Flexibility Supercoiling and Topoisomerases
More on Friday… Limitations to DNA Flexibility Supercoiling and Topoisomerases RNA Structure Nucleic Acid Function Recombinant DNA Technology Potentially PRS questions…

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