1. Molecular Immunology
Saverio Minucci

2. General informations PPT slides Exams: Official books: none X info:
home page:
Click on “didattica” :
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Exams:
team presentation of articles related to the topics discussed during the lessons
1 written test at the end of the course (open essay: 1 topic of your choice, 1 topic chosen by me)
Official books: none
Abbas/Lichtman (Basic Immunology- or italian translation)
Pier/Lyczak/Wetzler (Immunology, infection and immunity –or italian translation)
Whatever…
X info: o

3. A few questions for you…
What’s the difference between innate and adaptive immunity?
What can you say about innate immunity
Describe phagocytosis
How is the phagocyte attracted by its target?
How many types of adaptive immune responses do you know?
Can you give me one example of passive immunity?

4. Let’s define together the cardinal features of adaptive immune responses
Specificity
Diversity
Memory
Non reactivity to self

5. Adaptive immune response
What is a “naïve” T (or B) cell?
How is it that immune cells are able to avoid killing “self” cells?
What is the difference between a CD4+ and a CD8+ cell?
Which is the cell that is the main producer of antibodies?

6. Lymphocytes What’s the CD nomenclature?
What is the main difference among B and T lymphocytes?
Which are the main classes of effector T lymphocytes?
What is an APC? What’s the name of the most important class of APCs?

7. Phases of adaptive response
Antigen recognition
Lymphocyte activation
Effector Phase

8. Response to infective agents: an example

9. Topics to be addressed in the course
Vaccinations
Immunodeficiencies
Autoimmune diseases
Allergy
Microbiota
Cancer immunotherapy

14. Presentation Be “sharp”
In general, calculate 20’ max to discuss each article-review
Coordinate your work with the colleagues discussing the other papers
Ideally, the paper should be the stimulus to read also other papers….

15. How to structure the presentation
Reviews
Define the scope of the review
Define the biological problem tackled
Try to explain why it is important
Summarize the main findings described
Summarize what is in your opinion the “core message” of the review, what did you get out of it

16. How to structure the presentation
Article
Summarize the main findings
Why did the authors start this study?
Which are the key technologies used?
Describe the main results
Study the figures, try to find “weaknesses” in the paper
Summarize the conclusions
Does this paper in your opinion represent an incremental increase of our knowledge, or is it a ”great” paper, innovative in its field?
What did you get out of it