1. A human in vitro model to study new vaccines and novel agents
RESEARCH & INNOVATION SHOWCASE Dr Qibo Zhang-Senior Lecturer in Immunology
 A human in vitro model to study new vaccines and novel agents
Upper Respiratory Tract (URT) infections very common
Nasopharynx (NP) – portal of entry of pathogens
Immunity in NP first line of defence
In vitro model of upper airway immune system
Testing new vaccines/adjuvants/drugs
Adenotonsillar tissue
- Nasal-associated lymphoid tissue (NALT)
- Mucosal immune system in URI
- Induction site - natural immunity, intranasal vaccines
Immune Induction site
Collaborators: Novartis, AstraZeneca, Okairos

2. Adenoid cell culture Stimulus: Cytokines Human NALT +/- adjuvant
RESEARCH & INNOVATION SHOWCASE Dr Qibo Zhang-Senior Lecturer in Immunology
Adenoid cell culture
Adenoidal cells or PBMC
Tc, Bc, APC
Human NALT
Stimulus:
Vaccine Antigen
+/- adjuvant
T cell response
B cell
response
Cytokines

3. RESEARCH & INNOVATION SHOWCASE Dr Qibo Zhang-Senior Lecturer in Immunology
Tc resonse
Bc resonse
Cytokine resonse
Poster XX
1). Understanding protective immunity against infection in humans.
2). Development and evaluation of novel tvaccines/adjuvants/ herapeutic agents.
3). Advantage: relevant to humans
4). Collaboration with vaccine/pharmaceutical/ academic partners, on development and evaluation of novel agents.

4. A neat tool for translational research!