1. W7 3/20 WHOT
Copy down the following sequence of DNA and complete the complete the other half
ATTCAGATC

2. W7 3/21 WHOT Please turn in your toothpickase Lab.
List 3 things you learned from the video yesterday.
Weren’t paying attention? Sad.
Absent? The link is on the SWIFT, you need to watch the video and complete the WHOT before the end of the week.

3. DNA Structure Review 5’
These three components make up the nucleotide subunits of a DNA strand:
The nucleotides on each strand are held together using this type of bond:
If one strand is 5’ ATGTCA 3’, then the complimentary strand will be:
The two complimentary strands are held together using this type of bond:
Covalent
Hydrogen 3’

4. “It has not escaped our notice”
That the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.

5. Helicase Helicase breaks DNA into 2 separate strands. (unzips it)
Hydrogen Bonds

6. DNA Polymerase
DNA Polymerase adds on the complimentary bases to the new strands of DNA
DNA Polymerase builds the other side of the DNA A T
Covalent bond

7. DNA Structure Review
This enzyme separates the two strands of DNA during DNA replication:
During DNA replication, this enzyme adds nucleotides to a growing strand of DNA using the rules of complimentary base pairing:
DNA replication always proceeds in this direction:

8. 3/22 What are 2 enzymes involved in DNA replication:
What are they, and what do they do?

9. DNA Replication, How?
DNA is replicated Semi-conservatively.

10. DNA replication
DNA Polymerase: New strands of DNA are synthesized from the 5’  3’ direction.

11. DNA replication:
DNA Replication happens on both strands, in both directions:
But it’s not that simple:
Complimentary base-pairing (note that there is a mistake in this video!):
Okazaki fragments

12. Replication in Action
Replication occurs simultaneously at multiple places along a DNA strand.
Replication is as fast as 50 base pairs a second!
Humans have 3 billion Base pairs.
Note the liNobel e-Museum: DNA nk

13. 3/ WHOT
Describe what “semi-conservative” replication is.

14. Title: Linking Biology Ideas Together
(Cell Division)
Cell Size
In the circle: Write everything you know about these topics.
On the line: Write how the two topics in the circle are connected.
How is new genetic material made and transferred to new cells?
DNA Replication
Enzymes

15. Instructions: Create a detailed paragraph answering our Essential Question. Include important concepts about each idea in the bubble and the connecting ideas. You may use the template below to help organize your thoughts.

16. DNA is Universal
DNA structure - the double helix: same in all organisms
DNA replication process: essentially the same in all organisms.
All organisms need to unwind their DNA
All organisms use one “old” strand as a template to make a “new” strand
All organisms use the same nucleotides - ATGC
(Though, as demonstrated by Chargoff, in different ratios)
All DNA polymerases work in the 5’  3’ direction
DNA polymerase from bacteria is so similar to human DNA polymerase that it can be used to copy the DNA of humans!

17. Cracking the Code

18. W7 3/20 WHOT
Copy down the following sequence of DNA and complete the complete the other half
ATTCAGATC

19. W7 3/21 WHOT Please turn in your toothpickase Lab.
List 3 things you learned from the video yesterday.
Weren’t paying attention? Sad.
Absent? The link is on the SWIFT, you need to watch the video and complete the WHOT before the end of the week.

20. 3/22 What are 2 enzymes involved in DNA replication:
What are they, and what do they do?

21. 3/ WHOT
Describe what “semi-conservative” replication is.