1. M1 Spring 2009
29 April 8 00 AM
Neurotransmitter Transporters
Louis J De Felice, PhD
Physiology and Biophysics

2. synaptic transmission (2009)
action potential
invades synapse
neuron
Voltage-gated
ion channels
pre
vesicle
neurotransmitter
transporters
neurotransmitters
ligand-gated
ion channels
post
vesicular transporter

3. 5-HT NE
Epi DA
AMPH

5. glutamic acid

6. glutamate

7. GABA γ-Aminobutyric acid

8. Tyrosine > L-DOPA > DA > NE
<< OH
Tyrosine > L-DOPA > DA > NE

12. Antidepressant Medications -SSRIs-
Fluoxetine (Prozac)
Citalopram (Celexa)
Paroxetine (Paxil)

13. Monoamine Transporters and Disease
SERT
Obsessive Compulsive Disorder
Anxiety
Depression
IBS
serotonin
DAT
Attention Deficit/Hyperactivity Disorder
Drug Dependence
Schizophrenia
dopamine
NET
Orthostatic Intolerance
Depression
Hypertension
norepinephrine
(noradrenalin)

14. Closer look at the synapse
pre-synaptic vesicles