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Genetics of Brugada syndrome

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Presentation on theme: "Genetics of Brugada syndrome"— Presentation transcript:

1 Genetics of Brugada syndrome
Jyh-Ming Jimmy Juang, M.D., MS2, Ph.D., Minoru Horie  Journal of Arrhythmia  Volume 32, Issue 5, Pages (October 2016) DOI: /j.joa Copyright © 2016 Japanese Heart Rhythm Society Terms and Conditions

2 Fig. 1 An example of a representative multi-generation pedigree displaying incomplete penetrance (33%) and variable expressivity as some individuals display Brugada ECG without any cardiac events. Journal of Arrhythmia  , DOI: ( /j.joa ) Copyright © 2016 Japanese Heart Rhythm Society Terms and Conditions

3 Fig. 2 The flowchart for differentiating congenital BrS from acquired BrS before conducting genetic tests. Journal of Arrhythmia  , DOI: ( /j.joa ) Copyright © 2016 Japanese Heart Rhythm Society Terms and Conditions

4 Fig. 3 Schematic representation of a cardiomyocyte exhibiting the proteins involved in Brugada syndrome pathogenesis. Journal of Arrhythmia  , DOI: ( /j.joa ) Copyright © 2016 Japanese Heart Rhythm Society Terms and Conditions

5 Fig. 4 Genes associated with Brugada syndrome (BrS) and other inherited arrhythmia diseases. Journal of Arrhythmia  , DOI: ( /j.joa ) Copyright © 2016 Japanese Heart Rhythm Society Terms and Conditions


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