1. Eric Niederhoffer SIU-SOM
6/8/2018
Apoptosis
Fas
FasL
TNF
TNF-R1
Mit
TRADD
Cyt c
FADD
Caseff
Cas8
Protein degradation
DNase
FasL: Fas ligand (cytokines, interferons, interleukins) Fas: Fas surface receptor (CD95 or APO1)
FADD: Fas-associated death domain Cas8: cysteine-dependent aspartate-specific cysteine protease, caspase 8
Mit: mitochondrion Cyt c: cytochrome c Caseff: effector caspase TNF: tumor necrosis factor
TNF-R1: tumor necrosis factor receptor TRADD: tumor necrosis factor-associated death domain
DNase: deoxyribonuclease
Cell death
Eric Niederhoffer
SIU-SOM

2. Review Questions Which proteins are involved in apoptosis?
6/8/2018
Review Questions
Which proteins are involved in apoptosis?
What are caspases?
What is the function of caspases?
What is the function of cytochrome c?
What kinds of molecules are degraded during cell death?