1. A Challenging Case of Anticoagulant-Related GI Bleeding

3. Program Themes

4. Case Study: 71-Year-Old Man Presents to the ED

5. Current Medications

6. ED Evaluation (cont)

7. Rates of Oral Anticoagulation for AF

8. Frequency of GIB in Patients on Warfarin

9. Case Study: Warfarin Reversal

10. INR Reduction Comparison

11. Duration of Infusion Time and Total Volume(s) Infused (ITT Efficacy Population)

12. Management of Supratherapeutic INR

13. Vitamin K: Oral vs IV Routes for Warfarin Reversal

14. FFP vs 4-F PCC Advantages and Disadvantages

15. Consider What Degree of Resuscitation Is Needed

16. Intervention in GIB

17. Target INR for Endoscopy

18. Most Common Sources of Bleeding

19. Endoscopy in LGIB

20. Endoscopy in a Patient on OAC With a Nonvariceal Upper GIB

21. Return to Case: Ready for Discharge

22. Resumption of Warfarin

23. Consider Input of Full Team Regarding Reversal

24. Advantages 4-F PCC May Have Over FFP

25. Concluding Comments

26. Abbreviations

27. Abbreviations (cont)

28. Abbreviations (cont)