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Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology.

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Presentation on theme: "Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology."— Presentation transcript:

1 Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology of Major Mental Illnesses  Liisa Tomppo, William Hennah, Päivi Lahermo, Anu Loukola, Annamari Tuulio-Henriksson, Jaana Suvisaari, Timo Partonen, Jesper Ekelund, Jouko Lönnqvist, Leena Peltonen  Biological Psychiatry  Volume 65, Issue 12, Pages (June 2009) DOI: /j.biopsych Copyright © 2009 Society of Biological Psychiatry Terms and Conditions

2 Figure 1 DISC1 binding partners included in the study with partners grouped by common functions. DISC1, Disrupted in Schizophrenia 1; TNF, tumor necrosis factor; cAMP, cyclic adenosine monophosphate. Biological Psychiatry  , DOI: ( /j.biopsych ) Copyright © 2009 Society of Biological Psychiatry Terms and Conditions

3 Figure 2 Schematics show the regions of interest on chromosomes 1 (A), 5 (B), and 17 (C), where PDE4B, PDE4D, and NDEL1 are located, respectively, according to UCSC Genome Browser build 16 (released July 2003). Genotyped single nucleotide polymorphisms (SNPs) are indicated with vertical lines. Linkage disequilibrium (LD) structure describes the haplotype blocks that were tested for association. For the SNPs displaying association and SNPs included in the associating haplotype blocks, the rs-numbers are provided. Arrows above the schematics indicate direction from 5′ to 3′. Biological Psychiatry  , DOI: ( /j.biopsych ) Copyright © 2009 Society of Biological Psychiatry Terms and Conditions


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