1. Progress and Plans

2. Morning Meeting - Chemistry Room 1.53g
08:30 – 09:00 Coffee on arrival – Chaston Chapman Lounge
09:00 – 09:10 Welcome - John Blacker
09:10 – 10:10 Progress
Project Overview (John Blacker, Hayley Jackman)
TSB Crystallisation (Xue Wang)
Process Integration and Product Enhancement Through Crystal Growth Modifiers
TSB Immobilisation (Patrick McGowan)
10:10 – 10:30 Scale up Webinar Feedback
10:30 – 11:00 Coffee – Chaston Chapman Lounge
11:00 – 12:00 CDT projects Chris Rayner, Frans Muller
Break out to input into CDT projects
Seminar - Engineering, Houldsworth Building, LTB (1.06)
12:00 – 13:00 Buffet Lunch - Houldsworth, Coffee Bar and/or Foyer Area
13:00 – 13:10 Welcome - John Blacker (University of Leeds)
13:10 – 13:40 Molecular modelling - Simone Tomasi (AstraZeneca)
13:40 – 14:10 Fit for purpose modelling - Frans Muller (University of Leeds)
14:10 – 14:40 Combined CFD and PBM modelling of a gas-liquid reactor - Chris Rielly (University of Loughborough)
14:40 – 15:15 Coffee - Houldsworth, Coffee Bar and/or Foyer Area
15:15 – 15:45 Population balance modelling of crystallisation and solids processes: the importance of domain knowledge- Sean Bermingham (PSE Enterprise)
15:45 – 16:15 Finite/Discrete element modelling - Dr Bao H Xu (University of Leeds)
16:15 Close

3. Project Grants
EU FP7 outline proposal to Precision Manufacture of Nanoparticles (Limerick leading iPRD as partner) – alpha-rated unsuccessful but being re-iterated
Innovative Medicines Initiative looking at green (bio)synthesis methods
Chosen as preferred consortium - full application made. EU23m over 4 yrs. Consortium partners: 13 including iPRD, CoEBio3, York, Durham, Rostock, Antwerp, ACIB, Stuttgart, CatSci, Reaxa….
EPSRC Centre for Innovative Manufacture - EOI being submitted
Simon Biggs leading, with partners Uni Birmingham Chem Eng.
General area – Manufacture of functional (encapsulated) particles using continuous flow nano-membrane extrusion methodology
Wide sector application - seeking industrial partners
EPSRC Sustainable Chemical Feedstocks – Proposal being prepared (£2.5m)
Collaboration with iPRD, Warwick (Lapkin, Bugg), CoEBio3 (Turner)
General area – controlled biotransformation of lignin to simple polyphenolic broth and chemical modification to functionalised aromatic feedstocks

4. TSB Proposals
Call - Sustainable Manufacturing for the Process Industry
Project 1 – Predictive Work-Up. Currently discussing with AZ, KeyModule, Pfizer, Steven Abbott Associates, Chris Hunter (Sheffield), Peter Johnson (iPRD), Frans Muller (iPRD). Prediction of impurities traced through possible unit operations (mass balance); organic and aqueous solubility
Project 2 – Chiral Amines. Currently discussing with AZ, Pfizer, YPT, Dr Reddys, AM Tech, Jianling Xiao (Liverpool), J Blacker, P McGowan, Steve Marsden (iPRD). Use of immobilised Cp* catalyst system in flow with different reactions to make chiral heterocyclic amines.
Project 3 – Batch to Flow Catalyst Process. Currently discussing with CatExcel, J Blacker (iPRD). Advantages of carrying out a high energy transformation in flow.

5. MSc Projects
Scope and development of some aromatic nucleophilic substitution reactions. JB and with Lyn Powell at AstraZeneca. Student Mr Gabriel Moran Malagon
Direct asymmetric synthesis of chiral amines. JB and PM with Steve Fussel at Pfizer. Student Ms Nathalie Lam
Exploiting the reactivity of carbon dioxide in fine chemical and pharmaceutical processing. Chris Rayner and John Blacker
One-pot syntheses using multi-stage catalytic reactions. Steve Marsden and Simon Biggs
Scale-up of the DyeCat Process. Richard Blackburn and Chris Rayner (with DyeCat Ltd)
+ 3more

6. Traffic Light View on Internal/External Partners and Funding
UoL technology partners
External funding/collaborative partners
NMi
Astbury
Technology
Strategy
Board
EPSRC EU
Polymer
IRC
IPSE
Particle CiC
Healthcare
BHRC
Chemistry
Innovation
KTN
BIS
DCLG
iPRD
CPI
(Wilton)
IPI
(Bradford)?
BRITEST
CoEBio3
(M’cr)
IPOS
(H’field)
Industrial Club
(ca. 15 companies)
Strathclyde
CPACT?
UCL Biotech?
External technology partners

7. iPRD Sustainability Prof. Muller + 2 Fellows Dr Hayley Jackman
ERDF
YF Grant
Transformation Fund
HEIF5
Project grants
Contract work
Industrial Club
Prof. Muller
+ 2 Fellows
Business development manager
Dr Hayley Jackman
Could terminate Sept 2012
Staff Costs
Overheads
Equipment + Maintenance Consumables