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Naomi Fujioka, MD, Christopher A. French, MD, Michael J

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1 Long-Term Survival of a Patient with Squamous Cell Carcinoma Harboring NUT Gene Rearrangement 
Naomi Fujioka, MD, Christopher A. French, MD, Michael J. Cameron, BSc, Robert A. Kratzke, MD  Journal of Thoracic Oncology  Volume 5, Issue 10, Pages (October 2010) DOI: /JTO.0b013e3181ebaa20 Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

2 FIGURE 1 Hematoxylin and eosin staining of squamous cell carcinoma from the bronchus and lung. Portions of the tumor appeared to be well-differentiated squamous cell carcinoma (arrows), consistent with previous reports of nuclear protein of the testis (NUT) variants. BRD4-NUT tumors tend to exhibit less squamous differentiation. Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181ebaa20) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

3 FIGURE 2 Immunohistochemistry using a monoclonal antibody against nuclear protein of the testis (NUT). NUT midline carcinomas (NMCs) demonstrate diffuse speckled nuclear staining (arrows). This antibody has a sensitivity of 87% and specificity of 100% for NMCs.4 Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181ebaa20) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

4 FIGURE 3 Dual-color, split-apart fluorescent in situ hybridization for nuclear protein of the testis (NUT) gene rearrangement. The green and red probes flank the 15q14 NUT break point, and the signals are separated in NUT rearrangements (arrows). The most common NUT rearrangement is fusion of BRD4 on chromosome 19 to NUT on chromosome 15 forming the BRD4-NUT fusion gene. NUT variants form fusions with genes other than BRD4, including the highly homologous gene BRD3.2 Journal of Thoracic Oncology 2010 5, DOI: ( /JTO.0b013e3181ebaa20) Copyright © 2010 International Association for the Study of Lung Cancer Terms and Conditions

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