1. Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy 
Enriqueta Felip, Vera Hirsh, Sanjay Popat, Manuel Cobo, Andrea Fülöp, Charles Dayen, José M. Trigo, Richard Gregg, Cornelius F. Waller, Jean-Charles Soria, Glenwood D. Goss, James Gordon, Bushi Wang, Michael Palmer, Eva Ehrnrooth, Shirish M. Gadgeel 
Clinical Lung Cancer 
DOI: /j.cllc
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2. Figure 1 Questionnaire Completion Ratea
aOn the basis of completion of any item in the questionnaire. Cycle 1 is the baseline assessment since questionnaires were completed by patients before seeing the investigator and before any clinical assessment/treatment.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions

3. Figure 2 Proportion of Patients With Improvements in Symptoms
Abbreviations: GHS = global health status; OR = odds ratio (afatinib vs. erlotinib); QoL = quality of life.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions

4. Figure 3 Time to Deterioration of (A) Dyspnea, (B) Cough, (C) Pain
Abbreviation: HR = hazard ratio.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions

5. Figure 4 Time to Deterioration of Symptoms
Abbreviations: GHS = global health status; HR = hazard ratio; Q = question; QLQ-C30 = Quality of Life Questionnaire C30; QLQ-LC13 = Quality of Life Questionnaire Lung Cancer-13; QoL = quality of life.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions

6. Figure 5
Difference in Mean Scores Over Time for Cough, Dyspnea and Pain (A) and GHS and Functional Scales (B)
Abbreviations: GHS = global health status; Q = question; QLQ-C30 = Quality of Life Questionnaire C30; QLQ-LC13 = Quality of Life Questionnaire Lung Cancer-13; QoL = quality of life.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions

7. Supplemental Figure 1
Differences in Mean Scores for (A) Coughing, (B) Dyspnea, and (C) GHS/QoL in the Primary Analysis and Using Additional Data Cutoffs and Truncation Points
Abbreviations: GHS = global health status; QoL = quality of life.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions

8. Supplemental Figure 2
Time to Deterioration in Individual Items of (A) QLQ-C30 and (B) QLQ-LC13
Abbreviations: HR = hazard ratio; Q = question; QLQ-C30 = Quality of Life Questionnaire C30; QLQ-LC13 = Quality of Life Questionnaire Lung Cancer-13; QoL = quality of life.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions

9. Supplemental Figure 3
Difference in Mean Scores Over Time in Individual Items of (A) QLQ-C30 and (B) QLQ-LC13
Abbreviations: HR = hazard ratio; Q = question; QLQ-C30 = Quality of Life Questionnaire C30; QLQ-LC13 = Quality of Life Questionnaire Lung Cancer-13.
Clinical Lung Cancer DOI: ( /j.cllc )
Copyright © 2017 The Authors Terms and Conditions