1. Distributed profile of brain activity identified in a data-driven Principal Component Analysis combining patients with major depression and healthy matched control subjects in a positive emotional word condition, that correlates with group (diagnosis) membership. Note decreased cross-correlated ventral and medial striatal, medial prefrontal and precuneus activity, reflecting reward and default mode processing, in patients. With further developments and testing, such work may suggest patterns of circuit dysfunction distinguishing patients with depression or its subtypes, laying a foundation for future, clinically useful neuroimaging.
Source: Special Populations and Settings, Depression in Medical Illness
Citation: Barsky AJ, Silbersweig DA, Boland RJ. Depression in Medical Illness; 2016 Available at: Accessed: October 22, 2017
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