1. ^ Chest Diseases Ministry of health, Egypt
Beta2-adrenergic receptor gene haplotypes and bronchodilator response in COPD
Mohammad H. Hussein *, Khaled E. Sobhy, Irene M. Sabry, Ahmed T. El Serafi, Eman A. Toraih
^ Chest Diseases Ministry of health, Egypt
Inroduction
Results
Results (continue)
Chronic Obstructive Pulmonary Disease (COPD) is a multi-factorial disorder caused by environmental determinants and genetic risk factors. Understanding the genetic predisposition of COPD is essential to develop personalized treatment regimens. Beta2-adrenergic receptor (ADRB2) gene polymorphisms have been implicated in the pathogenesis of COPD. Aim: (1) association of Arg16Gly and Gln27Glu with COPD in the Egyptian patients, and (2) their impact on the clinical outcome and therapeutic response.
The Gly16 and Gln27 alleles represented 57% and 70% of whole study population, and only 3 haplotypes were detected; Arg16/Gln27, Gly16/Gln27, and Gly16/Glu27. Genotypes and haplotypes homozygous for Arg16 and Gln27 were more likely to develop COPD. Arg16 genotypes & haplotypes were associated with higher grades of dyspnea, more symptoms and frequent exacerbations. In contrast, Glu27 patients conferred protection against COPD development and had better bronchial airway responsiveness to β2-agonists.
Fig. 4. Bronchodilator response in COPD patients with different ADRB2 haplotypes.
Conclusion
Fig. 2. Haplotype analysis of ADRB2 gene polymorphism.
Our findings suggested that the ADRB2 polymorphisms may have vital role in COPD risk, severity, and bronchodilator response among Egyptian population. Larger epidemiological studies are needed for results validation.
References
Fig. 1. Structural features of b2-adrenergic receptor gene and protein.
Methods
Advances in Medical Sciences 62 (2017) 193–201
Contact
(1) Genotyping of .61 COPD patients and 54 Controls. (2) Pulmonary function test was done and repeated in patients after Salbutamol inhalation. 
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Fig. 3. Predicted functional impact of Gly16Arg and Gln27Glu.