1. Unified Theory of Diabetes and All Its Complications
Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimes and CV Benefits of DM Meds
*Environment=Genetic susceptibility to eg: poor diet,lack of exercise, sleep disorders,, food AGEs, Gut Biome **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome
MacroVascular
Damage
Inflammation
Immune Reg.
Polygenic
monogenic
epigenetic
Environment
Brownlee’s Unified
Theory of
Complications
Insulin Resistance-Part of
Cardiometabolic Syndrome with BP, Lipid
MicroVascular
Damage
*Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

2. Unified Theory of Diabetes and All Its Complications
Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimes and CV Benefits of DM Meds
All Complications
Biome G e N S In C O Mm n
Immune Reg.
Inflam
Cardiometabolic Syndrome with BP, Lipid
Ins Res.-Part of
Environment
epigenetic
Brownlee’s Unified
Theory of
Complications
Polygenic
monogenic
Epigenetics- via ROS/ miRNAs
Ins Res.-Part of
Cardiometabolic Syndrome
*Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

3. Unified Theory of Diabetes and All Its Complications
Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimes and CV Benefits of DM Meds
*Environment=Genetic susceptibility to eg: poor diet,lack of exercise, sleep disorders,, food AGEs, Gut Biome **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome
MacroVascular
Damage
Inflammation
Immune Reg.
Polygenic
monogenic
epigenetic
Environment
Brownlee’s Unified
Theory of
Complications
Insulin Resistance-Part of
Cardiometabolic Syndrome with BP, Lipid
MicroVascular
Damage
*Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

4. [Micro-MacroVascular
Unified Theory of Diabetes and All Its Complications
Most Mechanisms of B-Cell Damage (Hyperglycemia) Overlap with Causes of Vascular Disease : Provides Logic for Treatment Regimes and CV Benefits of DM Meds
*Environment=Genetic susceptibility to eg: poor diet,lack of exercise, sleep disorders,, food AGEs, Gut Biome **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome
ALL COMPLICATIONS
[Micro-MacroVascular
Damage]
Inflammation
Immune Reg.
Polygenic
monogenic
epigenetic
Environment
Brownlee’s Unified
Theory of
Complications
Insulin Resistance-Part of
Cardiometabolic Syndrome with BP, Lipid
*Environment=Genetic suceptibility to eg: viruses, endocrine disruptors, food AGEs, Gut Biome; **Insulin Resistance= Centrally Induced, Peripheral, Stress Hormones, Gut Biome

5. Unified Pathophysiologic Basis of Diabetes and Its Complications:
Implications for Understanding and Evaluating Risk, Diagnosis , Therapy