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Indirect chiral separation of 8 novel amphetamine derivatives as potential new psychoactive compounds by GC–MS and HPLC  Jennifer A. Weiß, Kian Kadkhodaei,

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Presentation on theme: "Indirect chiral separation of 8 novel amphetamine derivatives as potential new psychoactive compounds by GC–MS and HPLC  Jennifer A. Weiß, Kian Kadkhodaei,"— Presentation transcript:

1 Indirect chiral separation of 8 novel amphetamine derivatives as potential new psychoactive compounds by GC–MS and HPLC  Jennifer A. Weiß, Kian Kadkhodaei, Martin G. Schmid  Science and Justice  Volume 57, Issue 1, Pages 6-12 (January 2017) DOI: /j.scijus Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

2 Fig. 1 Chemical structures of the 8 synthesized and investigated amphetamine- and methamphetamine derivatives and their mass spectral data. Conditions: GC–MS, temperature programme 1; 1: 2-FMA, 2: 2-FA, 3: 3-BA, 4: 4-NA, 5: 2-CA, 6: 2-CMA, 7: 4-BMA, 8: 4-NMA. Science and Justice  , 6-12DOI: ( /j.scijus ) Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

3 Fig. 1 Chemical structures of the 8 synthesized and investigated amphetamine- and methamphetamine derivatives and their mass spectral data. Conditions: GC–MS, temperature programme 1; 1: 2-FMA, 2: 2-FA, 3: 3-BA, 4: 4-NA, 5: 2-CA, 6: 2-CMA, 7: 4-BMA, 8: 4-NMA. Science and Justice  , 6-12DOI: ( /j.scijus ) Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

4 Fig. 1 Chemical structures of the 8 synthesized and investigated amphetamine- and methamphetamine derivatives and their mass spectral data. Conditions: GC–MS, temperature programme 1; 1: 2-FMA, 2: 2-FA, 3: 3-BA, 4: 4-NA, 5: 2-CA, 6: 2-CMA, 7: 4-BMA, 8: 4-NMA. Science and Justice  , 6-12DOI: ( /j.scijus ) Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

5 Fig. 2 Chromatogram of the simultaneous separation of all 8 compounds with GC/MS. Order of elution: 1: 2-fluoroamphetamine; 2: 2-fluoromethamphetamine; 3: 2-chloroamphetamine; 4: 2-chloromethamphetamine; 5: 4-bromoamphetamine; 6: 4-bromomethamphetamine; 7: 4-nitroamphetamine; 8: 4-nitromethamphetamine. Science and Justice  , 6-12DOI: ( /j.scijus ) Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

6 Fig. 3 Chromatogram of the successful enantioseparation of 3 compounds with GC–MS; 1: 2-fluoroamphetamine, 2: 2-chloroamphetamine, 3: 4-bromoamphetamine; Conditions: temperature programme 2, derivatization with MTPA. Science and Justice  , 6-12DOI: ( /j.scijus ) Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

7 Fig. 4 Overlay of three chromatograms showing the enantioseparation of the three different fluoroamphetamines with GC–MS. 1: 2-fluoroamphetamine; 2: 3-fluoroamphetamine; 3: 4-fluoroamphetamine. Science and Justice  , 6-12DOI: ( /j.scijus ) Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

8 Fig. 5 Chromatogram of the simultaneous indirect chiral separation of 2-fluoroamphetamine (2), 3-fluoroamphetamine (1) and 4-fluoroamphetamine (3) with HPLC; Conditions: mobile phase: 2% sulfated beta-cyclodextrin in water pH 6: methanol (97.5:2.5), room temperature, flow: 1ml/min, UV: 270 nm. Science and Justice  , 6-12DOI: ( /j.scijus ) Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions

9 Science and Justice 2017 57, 6-12DOI: (10.1016/j.scijus.2016.08.007)
Copyright © 2016 The Chartered Society of Forensic Sciences Terms and Conditions


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