1. Nonproliferative DR (n=24)
Table 3. Serum concentrations of PON1 and biochemical parameters in patients with proliferative and nonproliferative
retinopathy and with DME
Nonproliferative DR (n=24)
Proliferative DR (n=24)
DR with DME (n=17)
DR without DME (n=31) p1 p2
PON1 (U/L)
126 (48-288)
59.5 (27-155)
190 (61-288)
62 (27-137)
<0.001†
HbA1C (%)
8.5±1.80
8.8±1.68
8.05( )
8.90( )
0.550‡
0.588†
Triglycerides (mg/dl)
136 (70-312)
138.5 (56-322)
139±70.5
171.2±72.2
0.787†
0.166‡
Total Cholesterol (mg/dl)
197±26.8
210±47.2
192±28.9
213±45.2
0.983‡
HDL (mg/dl)
47±9.06
46.5±6.4
46.8±9.07
46.5±6.47
0.754‡
LDL (mg/dl)
145 ( )
155.5 (85-219)
155±42.6
150±30.8
0.879†
0.451‡
NLR
2.59±1.52
2.61 ± 0.80
2.01( )
2.67( )
0.421‡
0.937†
Uric acid (mg/dl)
4.8 ( )
5.5 ( )
4.9( )
5.5( )
0.251†
0.165†
Hcy (umol/L)
14.4 ( )
16.0 ( )
14.2±3.13
17.4±8.28
0.581†
0.492‡
hsCRP (mg/L)
2.6 ( )
2.7 ( )
2.37( )
3.05( )
0.606†
0.659†
PON:hsCRP ratio
47.9 ( )
25.8( )
54 ( )
21.2 ( )
0.066†
† Mann Whitney U test, ‡ Student’s t test.
PON1: Paraoxonase 1 activity DR: Diabetic Retinopathy HDL: High-density lipoprotein LDL: Low-density lipoprotein NLR: Neutrophil-lymphocyte ratio Hcy: Homocysteine, hs-CRP: High-sensitivite CRP DME: Diabetic macular edema p1: Nonproliferative DR vs. Proliferative DR p2: DR with DME vs. DR without DME.
Narin NASIROGLU IMGA et al. Low Paraoxonase 1 Activity in Diabetes Mellitus as Predictors of Proliferative Diabetic
Retinopathy and Macular Edema. American Journal of Medical Sciences and Medicine, 2016, Vol. 4, No. 4,
doi: /ajmsm-4-4-2
© The Author(s) Published by Science and Education Publishing.