1. RADIOBIOLOGY: PART TWO

2. CELLULAR EFFECTS OF IRRADIATION
Instant death
Reproductive death
Apoptosis, programmed cell death(interphase death)
Mitotic or genetic death
Mitotic Delay
Interference of Function
Chromosome Breakage

3. Survival curves for Mammalian Cells
Shoulder indicates an area of cellular repair with Low LET exposures

4. Cell radiosensisitivy and Law of Bergonie and Tribondeau
Blood cells
Epithelial tissue
Muscle Tissue
Nervous Tissue
Reproductive cells
Blood Cells ???
Find the dose for
Whole body hematologic depression
What are stem or precursor cells?
What dose moderately to severely deplete bone marrow cells?
What are the most sensitive stems cells of human tissue?

5. Blood Cells -MORE QUESTIONS
Is death caused from high doses to red blood cells or white blood cells or platelets?Why?
What is the lethal dose for humans?
What dose level can impact lymphocytes and why is it so low?
Why are radiation patients monitored

6. Epithelial tissue
Muscle Tissue
Nervous Tissue
Radiosensitive
Insenstive
When are nerve cells most sensitive?

7. Reproductive cells Mature spermatogonia-sensitive or insensitive? Why?
What dose can cause temporary sterility in male? In female?
What dose can cause permanent sterility in male? In female?
Mature ova sensitive or insensitive?
What dose may suppress male sperm population?
When are a woman’s ovaries most sensitive?