1. Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration 
L. Lindberg, S. Brauer, P. Wollmer, L. Goldberg, A.W. Jones, S.G. Olsson 
Forensic Science International 
Volume 168, Issue 2, Pages (May 2007)
DOI: /j.forsciint
Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

2. Fig. 1
The test subject exhales freely into the opening of the cuvette of the analyzer.
Forensic Science International  , DOI: ( /j.forsciint )
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3. Fig. 2
(A) Differences between arterial blood alcohol concentration (ABAC, g/L) and breath alcohol concentration times 2251 (BrAC×2251, g/L) in the absorption period, 10–40min post-dosing, plotted against the average of the measurements indicating a slight underestimation by the breath measurement. Mean bias 0.033g/L and LOA −0.044g/L and 0.115g/L (N=59). (B) Differences between venous blood alcohol concentration (VBAC, g/L) and breath alcohol concentration times 2251 (BrAC×2251, g/L) in the absorption period, 10–40min post-dosing, plotted against the average of the measurements indicating a slight overestimation by the breath measurement. The wide LOA for the plotted values illustrate the large variability of the arterio(breath)-venous difference in the absorption phase. Mean bias −0.077g/L and LOA −0.228g/L and 0.075g (N=59). The horizontal unbroken lines show mean bias and the dotted lines 95% limits of agreement (LOA) (mean bias±1.96×S.D.).
Forensic Science International  , DOI: ( /j.forsciint )
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4. Fig. 3
Differences between arterial blood alcohol concentration (ABAC, g/L) and breath alcohol concentration times 2251 (BrAC×2251, g/L) in the post-absorption period, 50–420min post-dosing, plotted against the average of the measurements indicating good agreement. Mean bias g/L and LOA −0.025g/L and 0.033g/L (N=309). Differences between venous blood alcohol concentration (VBAC, g/L) and breath alcohol concentration times 2251 (BrAC×2251, g/L) in the post-absorption period, 50–420min post-dosing, plotted against the average of the measurements indicating a proportional bias. Mean bias 0.022g/L and LOA −0.034g/L and 0.078g/L (N=309). The linear regression model of the proportional bias was y (difference)=0.0586−0.0795×(average). The confidence interval for the slope (−0.0795) value was −0.090 to −0.068 indicating that the difference between VBAC and BrAC were statistically significant regardless of blood-to-breath ratio (p<0.001). The horizontal unbroken lines show mean bias and the dotted lines 95% limits of agreement (LOA) (mean bias±1.96×S.D.).
Forensic Science International  , DOI: ( /j.forsciint )
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5. Fig. 4
A scatter plot of arterial blood alcohol concentration (ABAC, g/L) and breath alcohol concentration times 2251 (BrAC×2251, g/L) in the post-absorption phase, 50–420min post-dosing, where N is number of x–y pairs and r is the correlation coefficient (p<0.001). The regression relationship is given by y (ABAC)= ×(BrAC×2251).
Forensic Science International  , DOI: ( /j.forsciint )
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6. Fig. 5
Differences between arterial blood alcohol concentration (ABAC, g/L) and breath alcohol concentration times 2251 (BrAC×2251) plotted against the time of sampling post-dosing for the whole experiment in 15 healthy volunteers. Mean±S.D. are plotted. **Statistically significant difference from zero according to one-way analysis of variance with LSD post hoc test for repeated measurements, p<0.05.
Forensic Science International  , DOI: ( /j.forsciint )
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7. Fig. 6
Differences between arterial blood alcohol concentration (ABAC, g/L) and venous blood alcohol concentration (VBAC, g/L) plotted against the sampling time post-dosing for the whole experiment in 15 healthy volunteers. Mean±S.D. are plotted. *Statistically significant difference from zero according to one-way analysis of variance with LSD post hoc test for repeated measurements, p<0.05.
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8. Fig. 7
Pharmacokinetic profile in one subjects showing concentrations of alcohol in arterial blood (ABAC), venous blood (VBAC) and breath (BrAC×2251) after oral ingestion of 0.6g of alcohol per kg body weight. The venous blood sample at 210min was not taken. The dotted lines illustrate the regression lines based on data points from 200min and onward according to zero-order kinetics (C=B−kt) for the three different concentration-time profiles. The slopes for the VBAC vs. time differed from the slopes for ABAC and BrAC×2251 vs. time.
Forensic Science International  , DOI: ( /j.forsciint )
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