1. SEMINAR
1. Title : Discovery of Protein-Protein Interaction Modulators Using Affinity-Based High-Throughput Screening
2. Speaker : Hyun-Suk Lim (포항공대 (POSTECH))
3. Time : 16:00 – 17:00, Thursday, May 11, 2017
4. Place : e+ Lecture Hall (room 83188), 2nd Research Building, Sungkyunkwan University
5. Summary : The majority of drugs on the market today target proteins with well-defined small-molecule binding sites, including enzymes. However, some of the most devastating diseases are caused by proteins that do not possess these natural binding sites, such as those involved in protein-protein interactions associated with many cancers. Synthetic molecules capable of inhibiting disease-related protein-protein interactions are thus valuable research tools to investigate molecular functions of target proteins and further could be developed as novel therapeutic candidates. However, discovering such inhibitors is a daunting task due largely to the relatively large and flat protein interfaces involved in protein-protein interactions. In general, typical drug-like small molecules may not be suitable to effectively cover such extended protein contact areas. As such, there is an urgent need for the development of different types of molecules to target protein interfaces. In addition, the shortage of convenient high-throughput screening methods is another important reason that makes the identification of such inhibitors so challenging. Here I will present our development of novel chemical entities capable of mimicking protein surface structure and function as well as simple and efficient high-throughput screening strategies that enables to facilitate the discovery of chemical inhibitors of many disease-causing protein-protein interactions.
6 Background :
Education
BS (Chemistry) Hanyang University
MS (Organic Chemistry) Hanyang University
PhD (Bioorganic Chemistry) POSTECH
Postdoctoral Fellow (Chemical Biology) University of Texas Southwestern Medical Center, USA
Work
Principal Research Scientist, Choogwae Pharma. Corp.
Assistant Professor, Indiana University School of Medicine, USA
2012-present Associate Professor, POSTECH
7. Questions : (☏ )