1. Ephitermal neutron source at Maria reactor
Current status Task to do Perspectives Summary
Ephitermal neutron source at Maria reactor
Dr eng. Michał A. Gryziński
IAEA Technical Meeting on
Research Reactor Users' Networks (RRUNs):
advances in neutron therapy
1 – 4 July 2013 Mainz, German
National Centre for Nuclear Research 1 1 1

2. Presentation overview
Current status Task to do Perspectives Summary
Presentation overview
1. Current status (projects performed untill now);
2. Task to do (ephitermal neutron flux in 2016);
3. Perspectives (projects planned according to possibilities);
4. Summary.
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90 2 2

3. National Centre for Nuclear Research
MARIA reactor Laboratory for Mixed Radiation Dosimetry
National Centre for Nuclear Research

4. 1. Current status (projects performed untill now);
2. Task to do (ephitermal neutron flux in 2016);
3. Perspectives (projects planned according to possibilities);
4. Summary.
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90 4 4

5. MARIA reactor in Świerk - selffinancing!
Molibdenium
Radiography
Radioisotopes production
Material research
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90
MARIA reactor in Świerk - selffinancing! 5 5

6. Channel H2 devoted to BNCT
Reactor MARIA 6 6

7. Channel H2 7 7 Statut 450 NCBiR-et4 60 NCBiR-et12 86 NCBiR-et13 110
169
NCN1 70
NCN2 90
Channel H2 7 7

8. Converter and EK-10 rods blok konwertera sonda konwerter podstawka
Cross section of the converter
Converter and EK-10 rods 8 8

9. Filter / moderator 9 9 Statut 450 NCBiR-et4 60 NCBiR-et12 86
110
NCBiR-et17
169
NCN1 70
NCN2 90
Filter / moderator 9 9

10. Medial channel H4 10 10 Statut 450 NCBiR-et4 60 NCBiR-et12 86
converter EK10
Vertical cross section
Horizontal cross section
Medial channel
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90
Medial channel 10 10

11. Medial channel podłączenia powietrzne obudowa kosza bloki berylowe
czoło kanału pośredniego
kompensator
element mocujący
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90
czoło kanału H2
Medial channel 11 11

12. 2. Task to do (ephitermal neutron flux in 2016);
1. Current status (projects performed untill now);
2. Task to do (ephitermal neutron flux in 2016);
3. Perspectives (projects planned according to possibilities);
4. Summary.
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90 12 12

13. Converter: recalculation, installation, control, dosimetry
reactor fuel
beryllium
graphite
converter
separator basket
Safety reasons 13 13

14. 3. Perspectives (projects planned according to possibilities);
Current status Task to do Perspectives Summary
1. Current status (projects performed untill now);
2. Task to do (ephitermal neutron flux achievable in close future);
3. Perspectives (projects planned according to possibilities);
4. Summary.
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90 14 14

15. Epithermal neutron source ~2∙109
The aim
1. Training/research BNCT stand (medical physics, oncologists)
2. Boron farmaceutics and imaging (transgenic mice FoxP3GFP and Pg-SPECT)
3. Neutron detectors nad dosimetry of the BNCT beam
4. Targeted BNCT (NeoBoron)
5. Another purposes (damages in materials, electronics and radiobiology)
Epithermal neutron source ~2∙109 15 15

16. Epithermal neutron source ~2∙109
Neutron beams:
H2 – epithermal
H1 – thermal (?)
Up to 6000h/year
Epithermal neutron source ~2∙109 16 16

17. Research/training BNCT17 17

18. Research/training BNCT
Pg-SPECT
Research/training BNCT 18 18

19. 1. Hirszweld Institute of Immunology and Experimental Therapy (Polish Academy of Sciences)
2. Institute of Medical Biology (Polish Academy of Sciences)
3. National Centre for Nuclear Research (POLATOM)
4. Faculty of Mechatronics (Warsaw University of Technology)
Scientific network 19 19

20. NeoBoron project 1. New boron carriers (carborans balls + proteins)
2. Transgenic mice FoxP3GFP (study on the effectiveness of inactivation of T-reg. cells)
3. Neutron beam position H2 (delivery system, video, and anesthesis)
NeoBoron project 20 20

21. New B-agents boronated cytidines
N-pinacolboronic and N-dihydroxyboronic derivatives of nucleosides containing dT, dU, dC moieties (methyl and ethyl-substituted 5’- or/and 3’-nitrogen atom(s))
boronic nucleosides
5’-boranophosphates containing T, dC, U and dU moieties
boron acyclic nucleoside phosphonates
New B-agents 21 21

22. Few types dedicated BNCT tested in April 2013 in Rez
Impovement of recombination chambers invented in Poland and designed for neutron dosimetry.
T5, G5 F1
F5, F6
Few types dedicated BNCT tested in April 2013 in Rez

23. 4. Summary. 1. Current status (projects performed untill now);
Current status Task to do Perspectives Summary
1. Current status (projects performed untill now);
2. Task to do (ephitermal neutron flux achievable in close future);
3. Perspectives (projects planned according to possibilities);
4. Summary.
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90 23 23

24. Epithermal neutron source ~2∙109
Current status Task to do Perspectives Summary
B-agents
(inteligent)
NeoBoron
(T-cells)
2016
Boron imaging
(Pg-SPECT)
Dosimetry for BNCT (full)
Statut
450
NCBiR-et4 60
NCBiR-et12 86
NCBiR-et13
110
NCBiR-et17
169
NCN1 70
NCN2 90
Epithermal neutron source ~2∙109 24 24

25. NeoBoron project 25 25 25

26. boron!!!
NeoBoron project 26 26 26

27. boron!!!
neutrons!!!
NeoBoron project 27 27 27

28. 2.Boron control 3.NeoBoron 1. accelerator T-reg cells + FOX-mice 28 28

29. Dziękuję za uwagę!!!
Recombination chambers

30. Konieczne jest wyznaczenie widma neutronów.
DT total absorbed dose
Components of absorbed dose
DB neutron capture on boron nucleus (α and 7Li)
Dg gamma (beam contamination and neutron capture on H)
Dn fast neutrons
DN protons comming from capture of thermal neutrons on nitrogen – reaction 14N(n,p)14C
Every dose components have different RBE, therefore everyhave to be determined separately
Konieczne jest wyznaczenie widma neutronów.
Doses… 30

31. + calculating codes (MCNP) Semiconductor detectors
Fission chamber
F1 F2
G-M
counter
GM1 GM2
Beam monitoring
Neutron fluence Φn
Total
absorbed
dose DT = DB + Dg + Dn + DN
Neutron fluence Φn
+ calculating codes (MCNP)
Activation detectors AM
Semiconductor detectors PN
TE/TE
Ioniz. chamber TE
Mg/Ar
Ioniz. chamber MA
TLD
detectors
Beam characterisation
How to deal? 31

32. Tissue equivalent chamber Recombination Microdosimetric method RMM
Beam monitoring
Tissue
equivalent
chamber
Chamber
filled with
BF3
Method RMM
Beam characterisation DT = Dg Dn DN +
Total
Absorbed
dose
Total dose
Quality factor
Tissue equivalent chamber
Two detector method
Recombination Microdosimetric method RMM DB
Filled with N2
Improvements
of methods
New methods
Recombination chambers 32

33. Recombination Microdosimetric Method RMM - unique method 1 10 100 1000
0.0
0.1
0.2
0.3
0.4
0.5 L D
[keV/ m m]
J(L )
RMM - unique method

34. Few types dedicated BNCT tested in April 2013 in Rez
Impovement of recombination chambers invented in Poland and designed for neutron dosimetry.
T5, G5 F1
F5, F6
Few types dedicated BNCT tested in April 2013 in Rez

35. Tissue equivalent chamber Recombination Microdosimetric method RMM
Beam monitoring
Tissue
equivalent
chamber
Chamber
filled with
BF3
Method RMM
Beam characterisation DT = Dg Dn DN +
Total
Absorbed
dose
Total dose
Quality factor
Tissue equivalent chamber
Two detector method
Recombination Microdosimetric method RMM DB
Filled with N2
Improvements
of methods
New methods
Tested in April 2013 35

36. Tissue equivalent chamber Recombination Microdosimetric method RMM
Beam monitoring
Tissue
equivalent
chamber
Chamber
filled with
BF3
Method RMM
Beam characterisation DT = Dg Dn DN +
Total
Absorbed
dose
Total dose
Quality factor
Tissue equivalent chamber
Two detector method
Recombination Microdosimetric method RMM DB
Filled with N2
Improvements
of methods
New methods
Under test now! 36

37. Thank you...
again
…for attention!!! 37 37 37