1. Established Status Epilepticus Treatment Trial (ESETT)
Drug Infusion Guide
HUM
Last Updated:

2. Step 1: Preparation by ED Pharmacist
If dose volume is ≤60mL:
Obtain appropriate size syringe depending on dosing volume
e.g., doses between 9-20mL, use 20mL syringe; doses between 21-30mL, use 30mL syringe; doses between 31 to 60mL, use 60mL syringe
Attach tubing
Draw-up volume of dose based on weight (from dosing chart) plus at least (more is fine) 1.1mL (fill volume of tubing = 1.1mL)
Prime line with drug by adjusting volume in syringe to dose volume (from the chart)
This should result in a syringe that reflects the correct dose volume and a primed line
If dose volume is >60mL:
Pharmacy to dispense full vials
ED RN will attach tubing (fill volume of this tubing is approximately 6mL)

3. Step 2: If Dose Volume is ≤60mL (Patient weight <60Kg) via Syringe
Nursing Staff
Step 2: If Dose Volume is ≤60mL (Patient weight <60Kg) via Syringe
Infuse IV over 10 minutes
Program infusion pump to deliver the volume/rate indicated on the dose administration chart
The volume and rate should be confirmed by a second nurse
Do not flush Alaris tubing after dose is infused
Disconnect line from T-Connector and discard before administering anything else to patient.
Keep vial for study team
Note: T-Connector does not need to be disconnected. The 0.55mL of fluid in T-Connector is okay.

4. Nursing Staff
Step 2: If Dose Volume is >60mL (Patient weight ≥60Kg) via Drug Vial
Open fill chamber vent for glass vial
Spike vial, prime line with drug
Prime line upside down as not to waste any drug
Connect study drug vial as primary infusion line
Note: Patient already have a line?
Connect ESETT drug as primary line so patient gets drug as soon as infusion starts!

5. Nursing Staff
Step 3: If Dose Volume is >60mL (Patient weight ≥60Kg) via Drug Vial
Program pump to deliver the volume/rate indicated on the dose administration chart
Second nurse confirm volume and rate
Infuse IV over 10 minutes, no pause
Note: Picture shows pump set to max dose of 90mL over 10 minutes

6. Nursing Staff
Step 4: If Dose Volume is >60mL (Patient weight ≥60Kg) via Drug Vial
When study drug bottle is empty and fill chamber running low/to keep the line from running dry:
*Un-spike drug vial, spike line with saline still using same primary infusion line
*Clinical team can use the Y or piggyback method when administering chase
This will need to be done to chase correct infusion dose through tubing
Do not flush Alaris tubing after dose is infused
Disconnect line from T-Connector and discard before administering anything else to patient.
Keep vial for study team
Note: T-Connector does not need to be disconnected. The 0.55mL of fluid in T-Connector is okay.

7. QUESTIONS? For routine questions, contact study team at 734-936-7715
For Immediate questions contact the ESETT study on-call at