1. Presented By Michael Lee at 2016 ASCO Annual Meeting
Association of primary site and molecular features with progression-free survival and overall survival of metastatic colorectal cancer after anti-epidermal growth factor receptor therapy
Presented By Michael Lee at 2016 ASCO Annual Meeting

2. Presented By Michael Lee at 2016 ASCO Annual Meeting
Learning Objectives
Presented By Michael Lee at 2016 ASCO Annual Meeting

3. Presented By Michael Lee at 2016 ASCO Annual Meeting
Background
Presented By Michael Lee at 2016 ASCO Annual Meeting

4. Presented By Michael Lee at 2016 ASCO Annual Meeting
Outline
Presented By Michael Lee at 2016 ASCO Annual Meeting

5. Clinical study population and methods
Presented By Michael Lee at 2016 ASCO Annual Meeting

6. Right-sided tumors are associated with inferior OS
Presented By Michael Lee at 2016 ASCO Annual Meeting

7. Presented By Michael Lee at 2016 ASCO Annual Meeting
Age, MSI, BRAF, and Methylation (CIMP) are associated with right-sided primaries
Presented By Michael Lee at 2016 ASCO Annual Meeting

8. … and these associated factors are also prognostic
Presented By Michael Lee at 2016 ASCO Annual Meeting

9. Side is not significant on multivariate analysis of OS
Presented By Michael Lee at 2016 ASCO Annual Meeting

10. Presented By Michael Lee at 2016 ASCO Annual Meeting
Right-sided primaries are more likely to have concomitant genetic features associated with poor outcomes
Presented By Michael Lee at 2016 ASCO Annual Meeting

11. Presented By Michael Lee at 2016 ASCO Annual Meeting
Outline
Presented By Michael Lee at 2016 ASCO Annual Meeting

12. Which factors impact efficacy of anti-EGFR therapy?
Presented By Michael Lee at 2016 ASCO Annual Meeting

13. Right-side is associated with inferior PFS with anti-EGFR therapy
Presented By Michael Lee at 2016 ASCO Annual Meeting

14. Tumor biology associated with poor response to anti-EGFR therapy
Presented By Michael Lee at 2016 ASCO Annual Meeting

15. Side is not significant on multivariate analysis of anti-EGFR PFS
Presented By Michael Lee at 2016 ASCO Annual Meeting

16. Presented By Michael Lee at 2016 ASCO Annual Meeting
Interim Conclusions
Presented By Michael Lee at 2016 ASCO Annual Meeting

17. Presented By Michael Lee at 2016 ASCO Annual Meeting
Outline
Presented By Michael Lee at 2016 ASCO Annual Meeting

18. Gene expression study population
Presented By Michael Lee at 2016 ASCO Annual Meeting

19. Established gene expression profiles
Presented By Michael Lee at 2016 ASCO Annual Meeting

20. Right-sided primary is associated with CMS 1 & 3
Presented By Michael Lee at 2016 ASCO Annual Meeting

21. Low EREG/AREG expression in right-sided primaries
Presented By Michael Lee at 2016 ASCO Annual Meeting

22. Presented By Michael Lee at 2016 ASCO Annual Meeting
Conclusions
Presented By Michael Lee at 2016 ASCO Annual Meeting

23. Presented By Michael Lee at 2016 ASCO Annual Meeting
Acknowledgements
Presented By Michael Lee at 2016 ASCO Annual Meeting