1. Catheter-related infection3
Supplementary File 12: Summary of reported complications from randomized trials fulfilling inclusion criteria.
Study
Hemodynamic
Instability1
Bleeding2
Catheter-related infection3
Thrombocytopenia4
Arrhythmia5
Hypoglycemia6
IHD
CRRT
Simpson [33] na
Kierdorf [26]
John [30]
6/10 (60)
9/20 (45)
0/10 (0)
3/20 (15)
Mehta [31]
Gasparovic [29]§
51/52 (98)
50/52 (96)
Augustine [27]
16/40 (40)
5/40 (12.5)
2/40 (5)
0/40 (0)
Uehlinger [34]
Vinsonneau[45]
72 (39)
61 (35)
13 (7)
12 (7)
2 (1)
3 (2)
22 (12)
31 (18)
18 (10)
9 (5)
7 (4)
Lins [46]
Abbreviations: IHD = intermittent hemodialysis; CRRT = continuous renal replacement therapy; na = not available or specified.
§ In this study, a hypotensive episode during RRT was defined as a decrease in mean arterial pressure 10 mmHg. Overall, 512 episodes occurred in patients receiving CRRT and 619 in those receiving IHD (p=0.14).[29]
1. Hemodynamic instability was defined as a decrease in mean arterial pressure 10% from baseline or any hypotensive episode prompting an increase in the dose of vasopressor infusion or need for fluid bolus.
2. A bleeding episode was defined by need for intervention or transfusion.
3. A catheter-related infection was defined as objective evidence of infection prompting either catheter removal or therapy with antibiotics.
4. Thrombocytopenia was defined as absolute platelet count <50,000/uL during RRT.
5. An arrhythmia was defined a clinically important supraventricular or ventricular tachy/bradyarrhythmia prompting therapy.
6. Hypoglycemia was defined as an absolute serum glucose <3.0mmol/L or an value prompting intervention.