Presentation is loading. Please wait.

Presentation is loading. Please wait.

Competitive brain and body growth model

Published bySamuel Jenkins Modified over 6 years ago

Similar presentations

Presentation on theme: "Competitive brain and body growth model"— Presentation transcript:

1 Competitive brain and body growth model
Predator Prey Team and Wolfram Solutions © Bill & Melinda Gates Foundation

2 Background and motivation
With sufficient nutrient intake, normal human development can support growth of body and brain along natural growth curves that vary from individual to individual. However, when nutrient intake is limited, these distinct development needs must compete for scarce energy resources, imposing a tradeoff between full brain and full body development for a given age. We propose a mathematical model that links the daily nutrient intakes to brain and body development. The model characterizes normative infant growth curves and is able to simulate different scenarios like regular feeding, catch-up growth and under- and over-nutrition based on changes in nutritional intake. Available energy generated from varied nutrient intake are assigned to different reservoirs. © Bill & Melinda Gates Foundation |

3 Competitive Brain and Body growth model
DAILY GROWTH SCHEME Individual state day N Daily growth function Individual state day N+1 Nutrient intake day N Global parameters The competitive brain and body growth model computes a growth trajectory of a single subject taking into account his daily nutrient intakes. The model is a recursion of a daily growth function, which takes as input the individual state for a particular day and the nutrient intakes and it returns the new individual state for the next day. The model spans from 0 to 5 years. © Bill & Melinda Gates Foundation |

4 nutrient intake 100% of requirement
Reservoir kcal Brain maintenance 116 Body maintenance 414 Brain development 168 Body development 17 Physical activities 82 nutrient intake 100% of requirement Caloric requirement: 889 kcal Individual state day N Caloric requirement function Reservoir kcal Brain maintenance 116 Body maintenance 414 Brain development 168 Body development 17 Physical activities 82 Nutrient intake day N 889 kcal Energy partition function Total energy repartition Reservoir gr Fat body mass 1.2 Lean body mass 6.3 Brain weight 1.6 Updated body measures Individual state day N+1 © Bill & Melinda Gates Foundation |

5 Nutrient intake 90% of requirement
Reservoir kcal Brain maintenance 116 Body maintenance 414 Brain development 168 Body development 17 Physical activities 82 Nutrient intake 90% of requirement Caloric requirement 889 kcal Individual state day N Caloric requirement function Nutrient intake day N 800 kcal Energy from body mass Reservoir kcal Brain maintenance 116 Body maintenance 410 Brain development 166 Body development 15.8 Physical activities 81 Nutrient intake + fat energy 870 kcal Energy partition function Total energy repartition Reservoir gr Fat body mass -5.3 Lean body mass 6.2 Brain weight 1.6 Updated body measures Individual state day N+1 © Bill & Melinda Gates Foundation |

6 Energy Competition Available energy generated from varied nutrient intake are assigned to different reservoirs (brain maintenance and its development, body maintenance and its development and physical activity). In case of underfeeding and malnutrition, these reservoirs will compete for the caloric resources. © Bill & Melinda Gates Foundation |

7 Model Results We first successfully characterized the normative growth curves associated with each percentile “growth channel” of the WHO standard growth curves. Several anthropometry data are tracked down. © Bill & Melinda Gates Foundation |

8 Model Results © Bill & Melinda Gates Foundation |

9 Fitting data We used the model to estimate the daily nutrient intakes for the first 5 years of a longitudinal Guatemala study (N =92). © Bill & Melinda Gates Foundation |

10 WHO Curves Percentile mobility
We can look at how, over time, the percentile an individual is in changes. The first column of dots refers to the computed percentile, while the following are calculated WHO percentiles: © Bill & Melinda Gates Foundation |

11 Further Directions The competitive brain and body growth model can be extended to the gestational period. © Bill & Melinda Gates Foundation |

Download ppt "Competitive brain and body growth model"

Similar presentations

Basis of a Healthy Diet How do we make good choices?

Basis of a Healthy Diet How do we make good choices?
Metabolism. Feasting Feasting adds to body stores of carbohydrate and fat Excess carbohydrate  used to fill glycogen stores  excess glucose stored as.

Metabolism. Feasting Feasting adds to body stores of carbohydrate and fat Excess carbohydrate  used to fill glycogen stores  excess glucose stored as.
THE CANADA FOOD GUIDE THE CANADA FOOD GUIDE Last Class Article for thought… fined-for-not-sending-ritz.html.

THE CANADA FOOD GUIDE THE CANADA FOOD GUIDE Last Class Article for thought… fined-for-not-sending-ritz.html.
School of Social and Community Medicine University of BRISTOL Longitudinal analysis of diet in ALSPAC Laura D Howe EUCCONET, Bristol, October 2011.

School of Social and Community Medicine University of BRISTOL Longitudinal analysis of diet in ALSPAC Laura D Howe EUCCONET, Bristol, October 2011.
NUTRITION FOR EXERCISES.  Macro Nutrients provide energy.  Fat, Proteins, Carbohydrates and Alcohol - calories.  Provide energy for body functions.

NUTRITION FOR EXERCISES.  Macro Nutrients provide energy.  Fat, Proteins, Carbohydrates and Alcohol - calories.  Provide energy for body functions.
Growth Diet The growth period is from weaning until 10-18 months of age. Puppies require 2-3 times the energy until they are 50% of adult weight. 1.5 times.

Growth Diet The growth period is from weaning until months of age. Puppies require 2-3 times the energy until they are 50% of adult weight. 1.5 times.
Estimating Daily Caloric Requirments Jennifer Tricoli.

Estimating Daily Caloric Requirments Jennifer Tricoli.
How do I calculate my daily calorie intake?. What is daily caloric intake (DCI)?  Daily Caloric Intake is a combination of 2 factors.  Basal Metabolic.

How do I calculate my daily calorie intake?. What is daily caloric intake (DCI)?  Daily Caloric Intake is a combination of 2 factors.  Basal Metabolic.
Outcomes: Discusses factors that limit and enhance the capacity to move and perform Analyses the benefits of participation and performance in physical.

Outcomes: Discusses factors that limit and enhance the capacity to move and perform Analyses the benefits of participation and performance in physical.
Nutrition and Physical Activity

Nutrition and Physical Activity
Reading Food Labels.

Reading Food Labels.
Obesity, Exercise and Weight Control HFIT 325 Exercise Physiology American University Reference book: Power’s 5 th Edition.

Obesity, Exercise and Weight Control HFIT 325 Exercise Physiology American University Reference book: Power’s 5 th Edition.
Chapter 3 Lecture Basic Chemistry Fourth Edition Chapter 3 Matter and Energy 3.6 Energy and Nutrition Learning Goal Use the energy values to calculate.

Chapter 3 Lecture Basic Chemistry Fourth Edition Chapter 3 Matter and Energy 3.6 Energy and Nutrition Learning Goal Use the energy values to calculate.
Nutrition SUBJECTIVE FINDINGS  1 month prior to consult, patient claimed to have lost 20-30% of her weight (can be classified as severe weight loss),

Nutrition SUBJECTIVE FINDINGS  1 month prior to consult, patient claimed to have lost 20-30% of her weight (can be classified as severe weight loss),
Glencoe Making Life Choices Section 5 Smart Weight-Loss Strategies Chapter 8 Nutrition: Healthy Body Weight 1 > HOME Content Vocabulary hunger.

Glencoe Making Life Choices Section 5 Smart Weight-Loss Strategies Chapter 8 Nutrition: Healthy Body Weight 1 > HOME Content Vocabulary hunger.
12/9/20151 Unit 5: Feeds, Nutrition and Digestion Lesson 4: Understanding Nutrients 2: Vitamins.

12/9/20151 Unit 5: Feeds, Nutrition and Digestion Lesson 4: Understanding Nutrients 2: Vitamins.
Xavier Mancero Statistics Division, ECLAC Seminar on poverty measurement Geneva, 5-6 May 2015.

Xavier Mancero Statistics Division, ECLAC Seminar on poverty measurement Geneva, 5-6 May 2015.
NUTRITIONAL DISORDERS Dr. Saleem Shaikh. Introduction Nutritional imbalance or disorders in a society generally depends on the socioeconomic conditions.

NUTRITIONAL DISORDERS Dr. Saleem Shaikh. Introduction Nutritional imbalance or disorders in a society generally depends on the socioeconomic conditions.
Gestation (pregnancy) In week 5, increase the energy intake by 30 – 60%. Due to the increased size of the uterus, offer several meals per day. During the.

Gestation (pregnancy) In week 5, increase the energy intake by 30 – 60%. Due to the increased size of the uterus, offer several meals per day. During the.
Energy and Calories. What are Calories Simple unit of measure for energy The amount of energy needed to rise 1 Gram of water 1 ° C Energy comes from 3.

Energy and Calories. What are Calories Simple unit of measure for energy The amount of energy needed to rise 1 Gram of water 1 ° C Energy comes from 3.

Similar presentations

Ads by Google