1. Promosome Corporate Introduction
6/12/2018
John F. Manzello President & CEO
369 Lexington Avenue, 17th Floor
New York, NY 10017
(508)

2. Promosome LLC
6/12/2018
Promosome is a New York City based biotechnology company with facilities in La Jolla CA and a research relationship with The Scripps Research Institute.
Founded in 2003 by the highly regarded life sciences team of John R. Costantino and William J. Gedale, to commercialize the discoveries of Nobel Laureate Dr. Gerald Edelman, his colleague Dr. Vincent Mauro and other researchers at The Scripps Research Institute in La Jolla, CA.
The expertise and continued focus of this research team at Scripps is in areas of Gene Regulation and Protein Expression through Translation Initiation.
Through this expertise the Scripps team has developed a world leading understanding of mRNA translation and has established several commercially applicable technologies with an emphasis on serving the therapeutic and industrial bioproduction space.

3. Promosome LLC & The Scripps Research Institute
6/12/2018
Promosome LLC & The Scripps Research Institute
The Scripps Partnership:
Promosome and TSRI are currently completing the third consecutive 2 Year Research Funding and Option (RFO) Agreement extension specific to the laboratories of Drs. Edelman and Mauro. Promosome and TSRI anticipate the relationship to continue into a fourth consecutive extension.
Through the RFO, Promosome has exclusive, sole, worldwide rights to license any and all translational discoveries related to bioproduction, DNA Vaccines and other applications developed under the funding arrangement.
Scripps holds a 10 % founder’s equity interest, subject to normal dilution – No Future Royalties.

4. Promosome LLC TEEs Translational Enhancing Elements
6/12/2018
Promosome is commercially leveraging the Scripps based knowledge through three significant bioproduction solutions relating to enhanced protein expression and mammalian cell line development.
TEEs Translational Enhancing Elements
RESCUE Reengineering mRNA Primary Structure for Enhanced Protein Production
Site Specific Chromosomal Integration - Landing Pad

5. TSRI / Promosome Invention Disclosure, Patent & License Process
6/12/2018
TSRI / Promosome Invention Disclosure, Patent & License Process
1. Promosome funds the laboratory and the specific research. (Through 2011)
2. Researchers discover technologies and submit as inventions to TSRI.
3. TSRI extends an Option to License to Promosome of said invention.
4. TSRI & Promosome jointly develop the patent strategy.
5. Patent is filed accordingly.
6. Promosome executes License Option.
7. Promosome initiates commercialization & sub-license strategies.
Collectively, these three technologies enable Promosome meet the most advanced transcription technologies in the marketplace through the introduction of our landing pad technology. This technology allows us to advance high expressing cell lines as well and as fast as any technology we are aware of.
Additionally, the TEEs then allow its translational function to be brought to bear on the protein synthesis component. This feature is unparalleled in the bioproduction industry.

6. TSRI / Promosome Invention Disclosure, Patent & License Process
6/12/2018
TSRI / Promosome Invention Disclosure, Patent & License Process
1. Promosome funds the laboratory and the specific research. (Through 2011)
2. Researchers discover technologies and submit as inventions to TSRI.
3. TSRI extends an Option to License to Promosome of said invention.
4. TSRI & Promosome jointly develop the patent strategy.
5. Patent is filed accordingly.
6. Promosome executes License Option.
7. Promosome initiates commercialization & sub-license strategies.
Collectively, these three technologies enable Promosome meet the most advanced transcription technologies in the marketplace through the introduction of our landing pad technology. This technology allows us to advance high expressing cell lines as well and as fast as any technology we are aware of.
Additionally, the TEEs then allow its translational function to be brought to bear on the protein synthesis component. This feature is unparalleled in the bioproduction industry.
TEE , RESCUE & Landing Pad Technologies

7. Technology License TEEs Translational Enhancer Elements
6/12/2018
Technology License
TEEs Translational Enhancer Elements
Provisional Patent Application - December 2007
License to Promosome – January 2008
Commercial Launch – January 2008
RESCUE Reengineering of mRNA Primary Structure for Enhanced Protein Expression
Provisional Patent Application – February 24, 2009
Licensed to Promosome – July 2009
PCT Patent Application - February 24, 2010
Launch for Commercialization / Sublicense – January 2011
Landing Pad Site Specific Chromosomal Integration (mammalian cells)
Invention released to TSRI - August 2009
TSRI Option to License to Promosome - August 2009
Provisional Patent Application Anticipated – March 2010
Licensed to Promosome – April 2010
Launch for Commercialization / Sublicense – April 2011
Collectively, these three technologies enable Promosome meet the most advanced transcription technologies in the marketplace through the introduction of our landing pad technology. This technology allows us to advance high expressing cell lines as well and as fast as any technology we are aware of.
Additionally, the TEEs then allow its translational function to be brought to bear on the protein synthesis component. This feature is unparalleled in the bioproduction industry.