1. Effects of three antiseizure drugs on sustained high-frequency firing of action potentials by cultured neurons. Intracellular recordings were made from neurons while depolarizing current pulses, approximately 0.75 s in duration, were applied (on-off step changes indicated by arrows). In the absence of drug, a series of high-frequency repetitive action potentials filled the entire duration of the current pulse. Phenytoin, carbamazepine, and sodium valproate all markedly reduced the number of action potentials elicited by the current pulses. (Adapted, with permission, from Macdonald RL, Meldrum BS: Principles of anti-epileptic drug action. In: Levy RH et al [editors]: Antiepileptic Drugs, 4th ed. Raven Press, 1995.)
Source: Antiseizure Drugs, Basic & Clinical Pharmacology, 13e
Citation: Katzung BG, Trevor AJ. Basic & Clinical Pharmacology, 13e; 2015 Available at: Accessed: October 24, 2017
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