1. Wales Neonatal Society Education Day
CARIS 2016
Annual meeting
Ysbyty Glan Clwyd
Royal Gwent Hospital
12th September 2016

3. EUROmediCAT euromedicat.eu
Prescribing of Antidiabetic Medicines before, during and after Pregnancy: A Study in Seven European Regions (PLOS ONE )
(wide variation in treatment for gestational diabetes, increased use of insulin analogues
no increased risk of congenital anomaly with insulin analogues)
Asthma medication prescribing before, during and after pregnancy:
a Study in Seven European regions (BMJ )
Risk of congenital anomalies after exposure to asthma medication in the first trimester of pregnancy – a cohort linkage study (BJOG )
(small excess risk of major congenital anomaly)
Selective serotonin reuptake inhibitor antidepressant use in first
trimester pregnancy and risk of specific congenital anomalies:
a European register-based study (EUR J Epidemiol )
(increased usage since 2004, much higher in UK, raised risk of heart defects but no overall excess of major anomalies)

4. Could a new test for Down's syndrome soon be made ... - WalesOnline
The simple blood test is used to detect the condition and can also pick up Patau’s and Edwards’ syndromes

7. The chance of the problem being seen on an ultrasound anomaly scan
at 18 to 20 weeks
Spina bifida %
(skin or bone not covering the spinal cord)
Spina bifida is a fault in the development of the
spine and spinal cord which leaves a gap in the
spine. The spinal cord connects all parts of the body to the brain.
Major heart condition, for example:
tetralogy of fallot %
Tetralogy of fallot is a serious heart condition where the heart has not developed in the same way as a normal heart in the womb.
This condition will need surgery usually in the first year of birth.
Data from: Welsh Congenital Anomaly Register and Information Service (CARIS)
(Accessed 23/06/2016)

9. 10 year rolling average of Trisomy 13 cases and outcomes – mean of all contributing registries
Goel N, Tucker D, Morgan M, 2016

10. 10 year rolling average of Trisomy 13 cases and outcomes – mean of all contributing registries
Goel N, Tucker D, Morgan M, 2016

11. %age Survival in Live births* T13 (countries without ETOP)
* Where outcome known = 239/394
Goel N, Tucker D, Morgan M, 2016

12. %age Survival in Live births* T13 (countries with ETOP)
* Where outcome known =1036/1159
Goel N, Tucker D, Morgan M, 2016