1. Metabolic normalization following liver-kidney transplantation in PH1
Metabolic normalization following liver-kidney transplantation in PH1. GFR, glomerular filtration rate (ml/min); Uox, urinary oxalate excretion (mmol/24 h in A and C and μmol/24 h/kg in B); Pox, plasma oxalate (μmol/liter); Uglycol, urinary glycolate excretion (mmol/24 h); = lower limit of normal for GFR or upper limit of normal for Uox, Pox, and Uglycol; abscissa = days after liver-kidney transplantation; pre-TX = representative values before liver-kidney transplantation. Note the slower normalization of Uox compared with Pox in A, the immediate normalization of Uglycol compared with Uox in C (see Fig ), and the apparent normalization of Uox after 200 days in B, followed by an increase in Uox over the next 300 to 400 days, presumably due to remobilization of bone CaOx deposits (see Fig ). (Data for panel A adapted with permission from Watts et al.469 ; extra data kindly provided by Dr. G. P. Kasidas, University College & Middlesex School of Medicine, London, and Dr. M. A. Mansell, St. Peter's Hospital, London. Panel B reproduced and modified with permission from Toussaint et al.473 ; original figure and data kindly provided by Professor C. Toussaint, Hopital Erasme, Bruxelles. Data for panel C taken with permission from Watts et al.469 ; extra data kindly provided by Professor L. H. Smith, Mayo Clinic, Rochester, MN.)
Source: Primary Hyperoxaluria, The Online Metabolic and Molecular Bases of Inherited Disease
Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: Accessed: October 24, 2017
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