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Characterization of Epstein-Barr virus–infected natural killer lymphocytes in a patient with hypersensitivity to mosquito bites  Takenobu Yamamoto, MD,

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Presentation on theme: "Characterization of Epstein-Barr virus–infected natural killer lymphocytes in a patient with hypersensitivity to mosquito bites  Takenobu Yamamoto, MD,"— Presentation transcript:

1 Characterization of Epstein-Barr virus–infected natural killer lymphocytes in a patient with hypersensitivity to mosquito bites  Takenobu Yamamoto, MD, Kazuyasu Fujii, MD, PhD, Kazuhide Tsuji, MD, PhD, Ayumi Akazai, MD, Megumi Oda, MD, PhD, Shosuke Imai, MD, PhD, Keiji Iwatsuki, MD, PhD  Journal of the American Academy of Dermatology  Volume 53, Issue 5, Pages (November 2005) DOI: /j.jaad Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 A, Histopathologic findings of ulcerative forearm lesion: necrosis and infiltration of lymphoid cells in subcutaneous tissue. Infiltrates consist of many lymphoid cells and a few atypical cells. B, Immunostaining of ulcerative lesion for CD56. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Clonal analyses for EBV DNA containing terminal repeats. Single band showing clonal proliferation of EBV-infected cells is observed at 8.0 kb in lane 3 (cutaneous lesion [forearm]) and lane 4 (NOY-2 cell) and at 20 kb in lane 5 (NOY-1 cell). No clonal band is detected lane 6 (bone marrow) and in lane 7 (peripheral blood mononuclear cells). Lane 1, Positive control (B95.8); lane 2, negative control; M, size marker. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions


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