1. Neurosis Department of Pathophysiology Lecture presentation
The State Education Institution of Higher Professional Training
The First Sechenov Moscow State Medical University
under Ministry of Health of the Russian Federation
 Department of Pathophysiology
Neurosis
Lecture presentation
Professor Pirozhkov S.V.
education year

2. MODELING OF NEUROSIS WITH PREDOMINANCE OF INHIBITION
● Use of conditioned stimulus of extreme intensity
● Exposure to simultaneous effects of several strong stimuli
● Exposure to the effect of complex conditioned or unusual stimuli

3. MODELING OF NEUROSIS WITH PREDOMINANCE OF EXCITATION
● Undue delays in providing food reinforcement
● Complex discrimination tasks
● The need to develop several different discriminations in one experimental session

4. ● Sudden change in the meaning of the conditioned stimulus
MODELING OF NEUROSIS WITH A PATHOLOGICAL LABILITY OF THE MAIN NERVOUS PROCESSES (EXCITATION AND INHIBITION)
● Sudden change in the meaning of the conditioned stimulus
● Abrupt change of the habitual environment
● Collision of different reflexes (for example, alimentary and defensive)

5. Neurosis – ● typical form of disorder of the higher nervous functions
● that is potentially reversible
● caused by psychological stress and
● characterized by disorders of mood, emotions, behavior, mentation, and general decrease of well-being without degradation of a personality or loss of judgment
● often accompanied by autonomous symptoms and, in some types, by disorders of sensation and locomotion

6. FACTORS THAT FOSTER INADEQUATE ADAPTATION IN NEUROTIC CONFLICT
● Faulty upbringing
● Negative experiences in early childhood or formative years of life
● Personal traits
● Hereditary predisposition
● Unfavourable circumstances, hard conditions of life

7. THE CORRESPODENCE OF CLASSICAL NEUROSES TO MODERN NOSOLOGICAL FORMS ACCORDING TO ICD-10
F40. Phobic disorders
(agoraphobia, social phobia etc.)
F42. Obsessive-compulsive
disorders
F44. Dissociative (conversion)
F45. Somatoform disorders
F48.0. Neurasthenia
Compulsion neurosis
Hysteric neurosis
Neurasthenia

8. DISSOCIATIVE (CONVERSION) DISORDERS
Characteristic features:
sudden, temporary alteration in the integrative functions of consciousness
loss of memory or identity
deficit of voluntary motor and sensory function
these deficits are temporary, and not intentionally produced or simulated

9. SOMATIZATION DISORDER
SOMATOFORM DISORDERS
HYPOCHONDRIASIS
SOMATIZATION DISORDER
A belief of serious illness that persists despite reassurance and appropriate medical evaluation
Preoccupation of a patient with somatic complaints with a focus more on specific symptoms rather than on fear of specific disease

10. Common phobias: ● Fear of closed spaces (claustrophobia)
● Fear of blood
● Fear of flying
● Social phobia
● Agoraphobia

11. Nucleus caudatum volume decrease
Pathophysiology of obsessive-compulsive disorders
Brain cortex
Motor cortex
Nucleus caudatum volume decrease
Orbitofrontal cortex
Alteration
Nucleus caudatum
Putamen
Basal ganglia
Globus pallidus
Substantia nigra
Brain stem
Thalamus

12. Neurasthenia ● emphasis on fatigability and weakness
● concern about lowered mental and physical efficiency
● unpleasant feelings of dizziness, tension, headaches, general instability, irritability, anhedonia
I type:
● complaint of increased fatigability after mental effort
● decrease in occupational performance or coping efficiency in daily tasks
II type:
● emphasis on physical weakness and exhaustion after only minimal effort
● feeling of muscular aches and pain and inability to relax