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Upper-Respiratory Viral Infection, Biomarkers, and COPD Exacerbations

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Presentation on theme: "Upper-Respiratory Viral Infection, Biomarkers, and COPD Exacerbations"— Presentation transcript:

1 Upper-Respiratory Viral Infection, Biomarkers, and COPD Exacerbations
Omar Kherad, MD, Laurent Kaiser, MD, Pierre-Olivier Bridevaux, MD, François Sarasin, MD, Yves Thomas, PhD, Jean-Paul Janssens, MD, Olivier T. Rutschmann, MD  CHEST  Volume 138, Issue 4, Pages (October 2010) DOI: /chest Copyright © 2010 The American College of Chest Physicians Terms and Conditions

2 Figure 1 Flowchart of patients included in the study. “Follow-up impossible” refers to patients transferred to another hospital. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

3 Figure 2 Viruses detected by polymerase chain reaction (PCR) in nasopharyngeal samples of 86 patients admitted for acute exacerbations of COPD (AECOPD) (black bars) and 71 patients who completed follow-up (white bars, stable period). RSV = respiratory syncytial virus. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

4 Figure 3 Seasonal variability of viruses detected by reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal swabs in patients admitted for AECOPD. See Figure 2 legend for expansion of abbreviations. CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

5 Figure 4 Seasonal variability of samples at baseline during admission (A) and at 4-month follow-up (B). CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

6 Figure 5 Serum CRP (n = 86) and procalcitonin (PCT) (n = 81) in patients with AECOPD. Five values are missing for PCT (two in the virus-positive group; three in the virus-negative group). Patients with (n = 20) and without bacterial infection (n = 68) identified by semiquantitative bacterial analysis of sputum at admission for AECOPD (A). Patients with (n = 44) and without (n = 42) viral nucleic acids identified by RT-PCR of nasopharyngeal swabs at admission for AECOPD (B). Data are expressed as medians (interquartile range). CHEST  , DOI: ( /chest ) Copyright © 2010 The American College of Chest Physicians Terms and Conditions


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