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Dementia Research and Enterprise at Liverpool John Moores University
Davide Bruno
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Overview Liverpool John Moores University is a public research university located in Liverpool city centre Close to 27,000 student + staff population Largest in Liverpool Post-1992 University
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Dementia Research and Engagement
Pragmatic Approach Centre for Collaborative Innovation in Dementia School of Art and Design Realistic Approach Institute for Health Research MeNu
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The Pragmatics
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Centre for Collaborative Innovation in Dementia
The centre works with partners (industry, academia, people living with dementia, PwD) to innovate and validate solutions for real life challenges Centre lead is Grahame Smith Located in Liverpool city centre
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Centre for Collaborative Innovation in Dementia
Health & Social Care Business Academia Service Users
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Centre for Collaborative Innovation in Dementia
Success stories Innovate Dementia: European funded project to innovate dementia care with PwD at the centre HELIUM: European funded, increase efficiency of public funding Health Enterprise Hub Innovation Exchange to grow business in Liverpool
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School of Art and Design
Design for Dementia From Amazon: “(…) Design Guide to assist designers (…) to tackle the challenges of dementia in society” Focus on Familiarity, dementia friendly neighbourhoods
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The Realists
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Institute for Health Research
Research, scholarship and knowledge exchange for lifelong health and well-being Understanding and changing behaviour Understanding and treating disease and illness Educating the workforce via evidence based practice
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Institute for Health Research
Cardiovascular Health Therapeutics Aging Digital health Sensors for Children’s Green Spaces Food, Nutrition and Health Workforce Education Image and Performance Enhancing Drugs
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MeNu: Research in memory and neurodegeneration
Based at LJMU, led by myself Part of a wide collaborative network
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Dementia: A global problem
Dementia prevalence expected to increase worldwide Emphasis on developing countries
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Early detection of neurodegeneration
Increasing importance of early detection Accuracy Accessibility Acceptance Cost Easy to use? Quick? Practical? Does it look scary? (Spinal tap) Do I have to learn something new? Does it look Useful to me? If familiar, probably yes.
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Triple-A Approach Employ cognitive testing (Accessible)
Transforming existing tools (Acceptable) Increase Accuracy
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Triple-A Approach Mobile technologies (phones, tablets); HEIF funding
Adapt existing cognitive tests Emphasis on serial position performance (Bruno et al., 2013; 2015; 2016; 2017)
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Serial Position Troyer (2011) Predictive of cognitive decline in high functioning older adults Predictive of MCI conversion over ~10 yrs Predictive of hippocampal volume
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Serial Position Also predictive of cognitive decline
Troyer (2011) Also predictive of cognitive decline Sensitive to Glutamate levels; measures of blood-brain barrier breakdown; and tau pathology
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Late-life Depression Major depression and depressive symptoms are linked to dementia, both AD and VaD But it is unclear whether this is a prodrome, a risk factor, a combination Also unclear why a person may progress and another may not
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Late-life Depression High-functioning depressed individuals 60+
Genetic, cognitive and biomarkers profile Main finding: Amyloid beta levels in CSF tend to fluctuate Correlate with depression severity rather than intellectual impairment
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On the Horizon Use of serial position-derived measure in conjunction with polygenic risk scores and non-APOE genetic risk factors The possible link between football play and CTE
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Summary Developing a few areas of inquiry in the dementia field
Some more pragmatic and focused on helping make a more dementia-friendly world And some more speculative and with a cognitive/neurobiological impetus
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Thank you Questions?
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