1. AIDS
Chien-Ming Li MD, Ph.D

2. Human Immuno-deficiency Virus (HIV)
Is an RNA virus
Causes AIDS: incurable
Multiplies inside CD4+ cells
Kills CD4 cells finally
Risk factors: Man-to-man sex, heroin abuser

3. Life cycle of HIV Binding and Fusion Reverse Transcription Integration
Assembly
Budding

4. Stages of HIV infection
Acute infection
Flu-like symptoms
Clinical latency
Free of symptom
Reproduces at very low level
May last 10 years or so
AIDS
CD4+ cells < 200 per cubic milliliter
Survives 3 years, without treatment

5. Anti-HIV drugs
NRTI: nucleoside analogue reverse transcriptase inhibitor
NNRTI: non-NRTI
PI: protease inhibitor
II: integrase inhibitor
FI: fusion inhibitor
CCR: chemokine coreceptor