1. Myocarditis in paediatric patients: age and gender are influencing incidence, severity and clinical course.
Initial data analysis from the German multi-centre registry “MYKKE”
Franziska Degener
46th Congress SICP Parma,

2. Registry for children and adolescents with suspected myocarditis
multi-center
prospective
pseudonymised
Inclusion criteria:
suspected myocarditis
hospital admission
age <18 years
informed consent
Data capturing on web interface, 52 items on characteristics, symptoms, diagnostic tests performed, confidence of the treating physician in the diagnosis on a subjective scale, left-ventricular function, therapy, complications. Items primarily require yes/no responses via ticking respective boxes, allowing for completing each data sheet in <5 minutes when all data are available.
DHZB | MYKKE: Initial data analysis | Parma

3. Participating centers
23 Zentren, 18 einschließend (nicht Ulm, Heidelberg, Stuttgart, Bonn, Oldenburg)
DHZB | MYKKE: Initial data analysis | Parma

4. Included patients (n=207)
DHZB | MYKKE: Initial data analysis | Parma

5. Age at symptom onset (n=207)
2 age peaks 0-<2 and years, young age distribution more 50/50, adolescents like overall 2/3 male
DHZB | MYKKE: Initial data analysis | Parma

6. Gender(n=207)
DHZB | MYKKE: Initial data analysis | Parma

7. Symptoms at admission (n=207)
Other: cardiogenic shock reanimation (4), gastrointestinal symptoms, edema, headache, paraesthesia
DHZB | MYKKE: Initial data analysis | Parma

8. Diagnostics (n=207)
DHZB | MYKKE: Initial data analysis | Parma

9. Ejection fraction according age groups (n=207)
0-<2=49, 2-12=41,13-18 =117
DHZB | MYKKE: Initial data analysis | Parma

10. Adverse Events according age groups (n=207)
Overall mortality 8/207 = 3,9% 1 DCM, 5 sicher myocarditis, 2x 3 und 2; alter 3x0, 1x2, 1x8, 11, 12, 13
DHZB | MYKKE: Initial data analysis | Parma

11. Therapy (n=206)
DHZB | MYKKE: Initial data analysis | Parma

12. Follow up EF in Echo (n=38)
Median Follow up 11 month
p<0.001
EF in %
Median 47% zu 60%, 56/207 haben FU 28%, davon 38/207 =18%, FU median 11 month
DHZB | MYKKE: Initial data analysis | Parma

13. Conclusion
MYKKE is a successful multicenter registry for myocarditis in children and adolescents
Data underline two age peaks (0-<2 years and years)
Severe clinical course and more adverse events are present in young children
Overall mortality of 3.9%
MYKKE serves as a platform for deriving diagnostic criteria and in future interventional studies
DHZB | MYKKE: Initial data analysis | Parma

14. Outlook End of 2016 Diagnostic criteria and a diagnostic score
2017 Standardized diagnostic in pediatric patients in Germany
Including another 150 patients
Validation of diagnostic criteria / score
2018 Data on Outcome in children and adolescents with myocarditis
Genetic / immunological analyses for understanding different pathomechanisms
2018 multi-center interventional therapy studies on myocarditis in children
Participating international centers
DHZB | MYKKE: Initial data analysis | Parma

15. Thank you. Deutsches Herzzentrum Berlin
Stiftung des bürgerlichen Rechts
Augustenburger Platz 1
13353 Berlin
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