1. SEMINAR 1. Title : Roles of microRNA in immune cell biology
2. Speaker : Tae-Don Kim, Ph.D.
(Korea Research Institute of Bioscience and Biotechnology, KRIBB)
3. Time : 16:00 – 17:00, Thursday, June 08, 2017
4. Place : e+ Lecture Hall (room 83188), 2nd Research Building, Sungkyunkwan University
5. Summary :
MicroRNAs play key roles in immune cell differentiation and immunity. Here, we show typical specimens involving miRNA effects on natural killer (NK) cell development, activation, and its homeostasis. During natural killer (NK) cell development, miR-583 plays an inhibitory role in IL-15 signaling by repressing CD132 required for NK cell differentiation. Upon stimulation, human miR-27a* and miR-150 are negative regulators of NK cell cytotoxicity by silencing perforin (Prf1) and granzyme B (GzmB) essential effector molecules for NK cell cytotoxicity. Thus, effector immune cells including NK cells are regulated by microRNAs, and modulating endogenous miRNA levels in effector immune cells represents a potential immunotherapeutic strategy for cancer.
6 Background :
Education
Ph.D., Dept. of Life science, POSTECH.
M.S., Dept. of Life Science, POSTECH.
B.S., Dept. of Genetic Engineering, Sungkyunkwan University.
Work
–Present: Professor, Dept. of Functional Genomics, UST
–Present: Principal Investigator , Immunotherapy Research Center, KRIBB
– : Visiting Scientist, University of Washington, Seattle. USA
– : Senior Research Scientist, Immunotherapy Research Center, KRIBB
– : Post-Doctoral fellow, Dept. of Life Science, POSTECH, Korea.
7. Questions : (☏ )