1. Supplemental Figure 1
Supplemental Figure 1: Electron Force Microscopy image of a DBS filter incubated with human blood.

2. Supplemental Figure 2
Supplemental Figure 2: Correlation of technical replicates in version 19 and 21 of the miRBase.

3. Supplemental Figure 3A n=30 samples p=60 miRNAs
Supplemental Figure 3A: Clustering of the lung cancer samples and process controls measured using version 19 of the miRBase.

4. Supplemental Figure 3B n=18 samples p=40 miRNAs
Supplemental Figure 3B: Clustering of the lung cancer samples and process controls measured using version 21 of the miRBase.

5. Supplemental Figure 3C
Supplemental Figure 3C: Correlation matrix of all samples. The process controls with highest correlation to each other can be observed in the lower right corner.

6. (all miRNAs expressed in at least 75% of all samples)
Supplemental Figure 4A
p=562 miRNAs
(all miRNAs expressed in at least 75% of all samples)
Supplemental Figure 4A: Averaged normalized expression intensity versus variance of expression intensity of process controls colored by the GC content.

7. (all miRNAs expressed in at least 75% of all samples)
Supplemental Figure 4B
p=562 miRNAs
(all miRNAs expressed in at least 75% of all samples)
Supplemental Figure 4B: Averaged normalized expression intensity versus variance of expression intensity of process controls colored by the miRBase version where each miRNA has been introduced to miRBase.