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Anti-inflammatory Therapy for Acute Lung Injury
Craig Metz, Ph.D. CHEST Volume 100, Issue 4, Pages (October 1991) DOI: /chest Copyright © 1991 The American College of Chest Physicians Terms and Conditions
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FIGURE 1 Major features in progression of animal and clinical pulmonary injury. TxB2, Thromboxane B2; PGI2, prostaglandin I2; HR, heart rate; FIo2, inspired oxygen tension; a/ao2 gradient, alveolar-arterial oxygen tension gradient; PMN, polymorphonuclear neutrophil Pa, mean arterial perfusing pressures; PEEP, positive end-expiratory pressure; LP/TP, lymph-to-plasma total protein ratios; CO, cardiac output; PMP, pulmonary microvascular permeability; and MPSS, methyprednisolone sodium succinate. CHEST , DOI: ( /chest ) Copyright © 1991 The American College of Chest Physicians Terms and Conditions
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FIGURE 2 Diagrammatic representation of arachidonic acid cascade, demonstrating where various anti-inflammatory agents discussed would modify production of vasoconstrictor and vasodilator prostaglandins. CHEST , DOI: ( /chest ) Copyright © 1991 The American College of Chest Physicians Terms and Conditions
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