1. The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis
Pharmacology 2013;92: DOI: /
Fig. 1. Relationship between potential sites of action and volume of distribution of common H1 antagonists (adapted from Tillement [22]). Volume of distribution values cited from Gillman et al. [91] and Chu et al. [92].
© 2013 S. Karger AG, Basel

2. The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis
Pharmacology 2013;92: DOI: /
Fig. 2. Binding affinity of histamine antagonists for human histamine H1 receptors (adapted from Gillard et al. [28]). Ki = Inhibition constant, the lower the amount of a drug needed to inhibit the H1 receptor, the higher its affinity.
© 2013 S. Karger AG, Basel

3. The Clinical Use of Cetirizine in the Treatment of Allergic Rhinitis
Pharmacology 2013;92: DOI: /
Fig. 3. Inhibition of the skin wheal formation in healthy volunteers following the intradermal injection of histamine, and after prior oral administration of different antihistamines (adapted from Grant et al. [37]). The inhibition of the flare formation was similar (not shown).
© 2013 S. Karger AG, Basel