1. Life Sciences Week – Strategy Day Lunch Event, September 25, 2013
PSI West
PSI East
SLS Techno-Trans AG; industrial use of the SLS facility at Paul Scherrer Institut PSI
Life Sciences Week – Strategy Day
Lunch Event, September 25, 2013

2. Agenda Intro about PSI & SLS Proprietary vs. academic research
How to access the SLS
Our partners
Contacts

3. Political embedment ETH Domain Swiss Federal Government EDA EDI EJPD
VBS
EFD
WBF
UVEK
(SBF)
ETH-Board
ETH Domain
ETHZ
Swiss Federal
Institute of
Technology
Zurich
EPFL
Swiss Federal
Institute of
Technology
Zurich
PSI
Paul Scherrer Institute
Empa
Swiss Federal
Laboratories
for Materials
Testing
WSL
Swiss Federal
Research
Institute for
Forestry, Snow
and Landscape
Eawag
Swiss Federal
Institute for
Water Resources and Water Pollution
Control
Founded in 1988 as a merger between two former single institutions (SIN and EIR)
PSI is part of the ETH domain (with ETH Zurich, EPF Lausanne, EMPA, EAWAG, WSL)
Largest research centre for natural and engineering sciences within Switzerland
Global budget 2012: 337 MCHF (275 M€) incl third party funding (EC, industry etc)
1500 FTE staff positions (+ 300 PhD), 35% scientist, 51% technicians/engineers, 7% administration
25% women, 47% non-Swiss staff
2012: # ISI publications: 1050 with PSI author/co-author 3

4. Mission
science of
matter and materials
energy and
environment
life sciences
large scale
research facilities
national and international users
academia and industry more than 2100 external users / year (38 beamlines)
development
construction
operation
knowledge &
expertise
education
technology
transfer
leading research on an international level – solid state physics and materials science – structural biology, molecular biology – radiochemistry, radiopharmacy, proton radiation therapy – particle physics, accelerator technologies with use of our large-scale facilities (SLS, SµS, SINQ und particle beams)
user laboratory for external scientific communities
energy research primarily using complex facilities towards an efficient, environmentally friendly and reliable energy supply
education and training in close collaboration with academic universities and universities of applied sciences
knowledge and technology transfer of our results towards new products and manufacturing processes in close partnership with industry 4

5. Energy research PSI East Materials sciences Nanotechnology Hotlab
Radio-Chemistry
Aare
Radio-Pharmacy
Solar concentrator
Proton accelerator
Biology
Neutron source SINQ
Muon source
Photon source SLS
Key figures
Staff: 1500
PhD students: 300
Postdocs: 100
External users: 2500
Proton therapy
PSI West

6. PSI offers three probes on one campus
Ideally suited for: solid state physics, soft condensed matter, chemistry, biology, materials science….
SLS: synchrotron X-rays
3rd generation synchrotron
electron energy: 2.4 GeV
operational: since 2001
beamlines: 18
SINQ: cold and thermal
neutrons
spallation neutron source
Thermal flux 1.1·1014n/cm2/s
operational: since 1998
instruments: 19
SmS: m-SR facilities
world’s most intense
continuous muon source
operational: since 1974/1989
instruments: 5

7. Academia vs. industry @ SLS
Approx. 10% of the beamtime is used by industrial users
2025 exp. d / 169 prop. exp. d
PX-Strahllinien: ca. 33% Nutzung durch die Industrie

8. World wide highest efficiency in resolving protein structures
SLS
World wide highest efficiency in resolving protein structures
European
Americas
Asian/Oceanic
Swiss Light Source
since 2002

9. How to access the SLS? Proprietary Access
We provide scientific consultations under the strictest confidentiality.
If this is necessary for your application, our contract office will arrange non-disclosure agreements (NDA) before any discussions take place.
Our major services are:
Providing an entry point for industrial SLS customers
Scientific consultations
NDA and contracts
Acquisition of new industrial/proprietary users

10. Proprietary access is supported by spin off companies and SLS TT AG
EXPOSE GmbH
Expose provides services on all aspects of protein crystallography to companies and organizations in the pharmaceutical and biotechnological sector. The company organizes measurement shifts at the Swiss Light Source (SLS) and carries out the corresponding analyses. Providing support for evaluations completes the range of services.
Contacts: Dr. Joachim Diez,
Dr. Santina Russo, Senior Scientist,
EXCELSUS STRUCTURAL SOLUTIONS
XRPD Characterization – qualitative and quantitative analysis of organic structures with privileged access to state-of-the-art Synchrotron-based techniques that allow an enhanced selection, precise identification, quality-by-design development and the highest attainable purity in the manufacturing of biotech, pharmaceutical, chemical and food products.
Contact: Dr. Fabia Gozzo,

11. From the first contact to the experiment
Contact to entry points
Techniques and Services
Contract
Experiment & Analysis
SLS TT AG
EXPOSE (PX)
EXCELSUS (XRPD)
BL-Scientists
SLS-TT AG
EXPOSE
EXCELSUS
SLS-Techno Trans AG
EXCELSUS: XRPD for pharma and food sector
BL-Team
EXPOSE
EXCELSUS
The user needs a DUO account (in case they do not yet have one 
The account needs an additional role, the 'Proprietary Research'. The role is assigned by the Useroffice
The company needs to sign a contract with the PSI/SLS technology transfer. Irene Waltert is the person to contact for such matters. 
The contract is usually limited to one (calendar) year and defines a certain amount of shifts.
Once the contract is signed, Irene could assign the number of shifts to the account created/defined under step 1|2. There is an administrative role in DUO called 'Proprietary Manager' for doing this.
In practice, especially towards end of the year, the shifts need to be "available on the account" before the contract issues is done. In those cases, the useroffice adds the shifts  to the account (also via the "Proprietary Manager" role). The request for these actions are typically triggered by the PX-Team.
The user could now take the available shifts and create proprietary proposals on any PX beamline with them. 
Those proposals could be scheduled directly  by the user on the shifts the beamline managers have marked as "Proprietary Research" (Cyan color).
Users with the 'Proprietary Research' role have functions to accomplish the above listed Step 7+8 on their DUO login page.  
In practice things work often different: Shifts are not marked as 'Proprietary' but the dates are negotiated by (like the current case) or the big customers send a list with desired shifts. The necessary proprietary proposals are then created by the user office Please always use 'Connect as this user...' button and create the proposal from the customers account by clicking 'Request proprietary research shifts', do NOT use the 'Add internal proposal').
The proposals created in Step 10 can used for Scheduling by the beamline-manager as any other Proposal.
2-4 weeks

12. Contacts SLS Techno Trans AG
c/o Paul Scherrer Institut
Stefan Müller
and phone
+41 (0)
Expose GmbH
Gabenstrasse 11
CH-5312 Klingnau
Joachim Diez & Santina Russo
and phone
+41 (0)
Excelsus Structural Solutions S.P.R.L.
93, Avenue du Hockey
1150 Brussels, Belgum
Fabia Gozzo
and Phone

13. Thank you for your attention