1. Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer#cod#x00027;s Disease Involves Nrf2/HO-1 Pathway
Morroni Fabiana 1 ;Sita Giulia 1 ;Graziosi Agnese 1 ;Turrini Eleonora 2 ;Fimognari Carmela 2 ;Tarozzi Andrea 2 ;Hrelia Patrizia 1 ;
1 Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Bologna, Italy ; 2 Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Rimini, Italy ;
Figure 8. Effects of CAPE 10 mgkg on GSK3 phosphorylation pGSK3 after A#cod#x003B2; 1-42 O injection. pGSK3 was determined 10 and 20 days after A#cod#x003B2; 1-42 O injection by Western Blotting at 46kDa using total GSK3 as loading control A. Top: representative images of the protein expression in hippocampus. Bottom: quantitative analysis of the Western Blotting results for the pGSK3 levels. The graphs show densitometry analysis of the bands appertaining to the protein of interest. Values are expressed as mean of fold increase #cod#x000B1; SEM n=10 of each group compared to the ShamVH group. GSK3 mRNA relative expression B was determined in hippocampal samples 10 days after A#cod#x003B2; 1-42 O injection through the 2 -#cod#x00394;#cod#x00394;Ct method. Rn 18S and ACTB were used as control housekeeping genes. Values are presented as mean #cod#x000B1; SEM of at least four different experiments A: #cod#x0002A;#cod#x0002A;p#cod#x0003C;0.01 vs. sham groups, #cod#x000A7; p#cod#x0003C;0.05 and #cod#x000A7;#cod#x000A7; p#cod#x0003C;0.01 vs. A#cod#x003B2;OVH group; B: #cod#x000A7; p#cod#x0003C;0.05 vs. A#cod#x003B2;OVH group; ANOVA, post hoc test Bonferroni.
null,null,0(0),null-null. Doi: /AD