1. Can we end aging?
林詩茵
邱淑敏
王雅佳
袁樂宜

2. Aging？

3. What is aging?
is a normal developmental factor and a continuous lifelong process that begins at birth and ends in death.
In humans, aging represents the accumulation of changes in a human being over time, encompassing physical, psychological, and social change.

4. “The theories of aging?”
Chronological aging
Biological aging
Psychological aging
Social aging

5. ABOUT THE SPEAKER

6. Aubrey de Grey English author and biomedical gerontologist.
Chief Science Officer of the SENS Research Foundation.
He works to identify and promote specific technological approaches to the reversal of various aspects of aging.

8. SENS Research Foundation
SENS = Strategies for Engineered Negligible Senescence
A US-registered charity that works to develop, promote and enable widespread access to regenerated medicine solution to the disabilities and diseases of aging.

9. SRF Education
SRF Education is trying to make the field of regenerative medicine comprehensible to everyone.
They offers a number of different options for student research.

10. Aging cause problems Costs Family members National Family Suffering
Tragedy

11. 20 years ago
8.8 adults ↓
1 elderly

12. NOW
5.6 adults ↓
1 elderly

13. 10 more years
3.2 adults ↓
1 elderly

14. Aubrey de Grey: What if we can end aging?
A car designed for only 15 years can last for 100 years
Why we cannot?
Human body is a machine

15. How aging makes us sick?

16. Metabolism
Damage
Pathology

17. Then How?

18. Damages Junk (inside/outside) Number of cells (too few/many) Mutations
Protein crosslinks

19. Robust Human Rejuvenation
Damage rising with age
Method
Cell loss, cell atrophy
Cell therapy
Extracellular junk
Phagocytosis by immune stimulation
Extracellular crosslinks
AGE-breaking molecules/enzymes
Death-resistant cells
Suicide genes, immune stimulation
Mitochondrial mutations
Allotopic expression of 13 proteins
Intracellular junk
Transgenic microbial hydrolases
Nuclear [epi] mutations
(cancer related matters)
Telomerase/ALT gene deletion plus periodic stem cell reseeding

20. Telomerase therapy

21. Prevention

22. Have fun

23. We seem to have a good future…

24. But wait

25. Our final method