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Facilitating pharmacometric workflow with the metrumrg package for R

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Presentation on theme: "Facilitating pharmacometric workflow with the metrumrg package for R"— Presentation transcript:

1 Facilitating pharmacometric workflow with the metrumrg package for R
Timothy T. Bergsma, William Knebel, Jeannine Fisher, William R. Gillespie, Matthew M. Riggs, Leonid Gibiansky, Marc R. Gastonguay  Computer Methods and Programs in Biomedicine  Volume 109, Issue 1, Pages (January 2013) DOI: /j.cmpb Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Kinetics: visualization of concentration–time profiles with dosing history. Units are arbitary for this example; see text. (For interpretation of the references to color in the text, the reader is referred to the web version of the article.) Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Covariate effects on clearance: visualization of bootstrap parameter estimates. CL: typical clearance. Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Diagnostics: observed concentrations vs. model-based individual and population predictions. Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 4 Median overlay: using actual times (left) vs. “snapped” times (right). Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

6 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

7 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

8 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

9 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

10 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

11 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

12 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

13 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

14 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

15 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

16 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

17 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

18 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

19 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

20 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

21 Computer Methods and Programs in Biomedicine 2013 109, 77-85DOI: (10
Computer Methods and Programs in Biomedicine  , 77-85DOI: ( /j.cmpb ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

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