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Steven Baroletti, PharmD, MBA, Shelley Hurwitz, PhD, Nicole A. S

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Presentation on theme: "Steven Baroletti, PharmD, MBA, Shelley Hurwitz, PhD, Nicole A. S"— Presentation transcript:

1 Thrombosis in Suspected Heparin-induced Thrombocytopenia Occurs More Often with High Antibody Levels 
Steven Baroletti, PharmD, MBA, Shelley Hurwitz, PhD, Nicole A.S. Conti, PharmD, John Fanikos, RPh, MBA, Gregory Piazza, MD, Samuel Z. Goldhaber, MD  The American Journal of Medicine  Volume 125, Issue 1, Pages (January 2012) DOI: /j.amjmed Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Association of anti-PF4/heparin antibody level with any arterial or venous thrombosis and pulmonary embolism. The proportion with any thrombosis by 30 days and the proportion with pulmonary embolism are shown as a function of anti-PF4/heparin antibody level. Increases in anti-PF4/heparin antibody level were significantly associated with greater proportions of any thrombosis and pulmonary embolism by 30 days. PE=pulmonary embolism; PF4=platelet factor 4; OD=optical density. The American Journal of Medicine  , 44-49DOI: ( /j.amjmed ) Copyright © 2012 Elsevier Inc. Terms and Conditions

3 Figure 2 Observed and predicted thrombosis proportion according to anti-PF4/heparin antibody level and 95% confidence band. CI=confidence interval; PF4=platelet factor 4. The American Journal of Medicine  , 44-49DOI: ( /j.amjmed ) Copyright © 2012 Elsevier Inc. Terms and Conditions


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