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A high-throughput urinalysis of abused drugs based on a SPE-LC–MS/MS method coupled with an in-house developed post-analysis data treatment system  Wing-Chi.

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Presentation on theme: "A high-throughput urinalysis of abused drugs based on a SPE-LC–MS/MS method coupled with an in-house developed post-analysis data treatment system  Wing-Chi."— Presentation transcript:

1 A high-throughput urinalysis of abused drugs based on a SPE-LC–MS/MS method coupled with an in-house developed post-analysis data treatment system  Wing-Chi Cheng, Tsan-Sang Yau, Ming-Kei Wong, Lai-Ping Chan, Vincent King-Kuen Mok  Forensic Science International  Volume 162, Issue 1, Pages (October 2006) DOI: /j.forsciint Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

2 Scheme 1 Schematic diagram showing the workflow of the urinalysis system. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 1 The representative selective ion chromatograms of urine spiked with standards at cut-off concentrations. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 2 (a) An example of an “semi-quantitative summary sheet (page 1)” and (b) “semi-quantitative summary sheet (page 2)” for benzodiazepines. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

5 Fig. 3 A typical “library search sequence” for “positive” in semi-quantitative analysis found in the sequence 0721MKAO_T generated by the macro-program. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

6 Fig. 4 (a) An example of “library search summary sheet (page 1)” and (b) “library search summary sheet (page 2)” for all benzodiazepines. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

7 Fig. 5 A hardcopy of the data transferred from macro-program to central database. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions

8 Fig. 6 An example of the compiled report for sample, UCN 3639, which included selective ion chromatograms, semi-quantitation report and MS/MS matching data. Forensic Science International  , DOI: ( /j.forsciint ) Copyright © 2006 Elsevier Ireland Ltd Terms and Conditions


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