1. Development of Harvard Catalyst Imaging Consultation Service
C.Tempany, MD; R.Kikinis, MD; R.Gollub,MD,PhD; V. Humblet, PhD
February 27,2009

2. Technology and Expertise IT Structure Why be a consultant ?
Agenda
Harvard Catalyst
Imaging Consortium
Technology and Expertise
IT Structure
Why be a consultant ?
Educational Opportunities
Contact

3. Harvard Catalyst: The Basics
We are a pan-Harvard enterprise dedicated to improving human health by:
Creating Connections
Enabling research At the Cutting Edge of discovery
Nurturing clinical and translational researchers 2

4. National Effort in C/T Research
We are supported by a Clinical and Translational Science Award (CTSA) awarded by the NIH’s National Center for Research Resources (NCRR) in May 2008, as well as commitments from many of our partner institutions.
We are a member of NCRR’s CTSA Consortium (see map), a group of 38 academic health centers nationwide with NIH-supported programs for clinical and translational research.
Source:
Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium 3 3

5. Institutions participating in Harvard CTSC
 Academic Healthcare Centers
Beth Israel-Deaconess Medical Center
Brigham and Women’s Hospital
Massachusetts General Hospital
Children’s Hospital Boston
Specialty Hospitals and Institutes
Dana-Farber Cancer Institute
Forsyth Dental Institute
Joslin Diabetes Center
Massachusetts Eye and Ear Infirmary
McLean Hospital
Schepens Eye Research Institute
Massachusetts Institutes of Technology
Harvard University
Faculty of Arts and Sciences
Harvard Business School
Harvard School of Dental Medicine
Harvard Divinity School
Graduate School of Design
Graduate School of Education
Kennedy School of Government
Harvard Law School
Harvard Medical School
Harvard School of Public Health
Harvard School of Engineering
Community Healthcare Institutions
Cambridge Health Alliance
HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 4

6. Imaging Consortium Team
Bruce Rosen, Director
Randy Gollub, Co-Director
Gordon J. Harris, Site Co-Director
Robert Lenkinski, Site Co-Director
Neil Rofsky, Site Co-Director
Clare Tempany, Site Co-Director
Ron Kikinis, Site Co-Director
Gordon Williams, PI for CTSC Translational Technologies
Stephan Voss, Site Co-Director
Simon Warfield, Site Co-Director
Annick D. Van den Abbeele, Site Co-Director
Jeff Yap, Site Co-Director
William Hanlon, Core Manager
Valerie Humblet, Imaging Liaison 5

7. Mission of the Imaging Consortium
Provide expert consultation and guidance to CTSC participants in the use of imaging as part of clinical translational research
Educate and advise Harvard and the Affiliated Academic Health Centers about available imaging and image processing capabilities in the Harvard environment. 6

8. Harvard Catalyst website
Access to resources and profiles 7

9. Image Consortium Consultation Service
Access to the consultation service: 8

10. Technologies and Expertise
Cancer imaging, MRI, PET, CT, fMRI, pediatric imaging, neuroimaging.
Focused on assisting with planning and design of research proposals and/or methods for image analysis.
Consultation is available for the preparation of a grant or IRB submission.
We do not provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 9

11. XNAT-PACS-i2b2 Integration
IT Catalyst infrastructure:
i2b2: scalable computational framework to help translation of genomic findings.
BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups.
NA-MIC:robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: slicer. Freesurfer. 10

12. XNAT-PACS-i2b2 Integration
Dr Y
Desktop Alzheimer
Dr Z
Desktop Chronic pain management
Dr X Desktop Pediatric rare disease
Dr W
Desktop Quantitative cancer biomarkers
XNAT
Enterprise
PACS
PACS
Project
Management
Annotating
Genomic
Data #2
File
Repository
De -
Identification
Of data
Ontology
Management
Identity
Management
Natural
Language
Processing
Slicer:
Data visualization analysis
Data
Repository
(CRC)
Workflow
Framework
Annotating
Genomic
Data #1
Correlation
Analysis 11
i2b2 HIVE

13. Becoming an Imaging Consultant
Potential benefits of being an active collaborator:
Good framework for research
Research opportunities through collaborations
Meeting experts out of radiology
Networking with imaging cores outside of Boston
Example: standardization of physiologic monitoring system for fMRI 12

14. Educational Opportunities proposal
Nanocourse: Imaging 101
More advanced classes:
Tumor metrics
Radiation safety issues for IRB submission
Hands-on classes on data analysis
Imaging perfusion
Example: 13

15. http://catalyst.harvard.edu Image_Consult@catalyst.harvard.edu