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Regional generation of free oxygen radicals during cardiopulmonary bypass in children  Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri.

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Presentation on theme: "Regional generation of free oxygen radicals during cardiopulmonary bypass in children  Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri."— Presentation transcript:

1 Regional generation of free oxygen radicals during cardiopulmonary bypass in children 
Eero J. Pesonen, MDa, Reijo Korpela, MDa, Kaija Peltola, MDa, Mauri Leijala, MDa, Heikki Sairanen, MDa, Kari O. Raivio, MDa, Per Venge, MDb, Sture Andersson, MDa c  The Journal of Thoracic and Cardiovascular Surgery  Volume 110, Issue 3, Pages (September 1995) DOI: /S (95) Copyright © 1995 Mosby, Inc. Terms and Conditions

2 Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

3 Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

4 Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

5 Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

6 Fig. 1 Mixed venous concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO). Preoperative values corrected for hemodilution during CPB are depicted with dots. †p < 0.05, ††p < 0.01, and †††p < versus 0 minutes; *p < 0.05 and **p < 0.01 versus 40 minutes aaaafter the onset of CPB (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

7 Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

8 Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

9 Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

10 Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

11 Fig. 2 Mixed venous temperature (V-TEMP) and differences in plasma concentrations of malondialdehyde (MDA), hypoxanthine (HX), urate (UR), lactoferrin (LF), and myeloperoxidase (MPO) between the IVC and the arterial line of the oxygenator. †p < 0.05, ††p < 0.01, for IVC versus A (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

12 Fig. 3 Plasma lactoferrin (LF) and myeloperoxidase (MPO) concentration differences between arterial and venous lines of the oxygenator. †p < 0.05 and ††p < 0.01 for arterial versus venous line (Wilcoxon test). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /S (95) ) Copyright © 1995 Mosby, Inc. Terms and Conditions

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