1. ALL Interfant EsPhALL ALL11 ALL11 Down ALL11 SR ALL11 MR ALL11 HR
Age <366 days
Interfant
t(9;22)/BCR-ABL+
EsPhALL
ALL11
Down syndrome
ALL11 Down
*no anthracyclines in induction
*reduced MTX dose in prot M
No CR at day 33 or t(4;11)/MLL-AF4+
MRD
MRD
MRD MR or unknown or HR
MRD SR
MRD MR or unk
MRD HR
MRD SR
PPR
CNS or testis involvement
PPR
CNS or testis involvement
ALL11 SR
ALL11 MR
ALL11 HR
ALL11 SR Down
ALL11 MR Down
3 yr therapy incl anthracyclines
IKZF del
SCT ind
3 yr therapy incl anthracyclines in intensification
IKZF del
SCT
2 yr therapy
no anthracyclines in intensification
TEL/AML+
No SCT ind
2 yr chemoth
2 yr therapy incl anthracyclines
2 yr therapy no anthracyclines